ST8SIA2 Antibody

Datasheet

Code	CSB-PA852840ESR2HU
Size	US$166
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Image	Western blot All lanes: Alpha-2, 8-sialyltransferase 8B antibody at 8μg/ml Lane 1: Mouse heart tissue Lane 2: HepG2 whole cell lysate Lane 3: Mouse kidney tissue Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 42 kDa Observed band size: 42 kDa Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA852840ESR2HU at dilution of 1:100 Immunofluorescent analysis of HepG2 cells using CSB-PA852840ESR2HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ST8SIA2 Polyclonal antibody

Uniprot No.

Q92186

Target Names

ST8SIA2

Alternative Names

ST8SIA2 antibody; SIAT8B antibody; STX antibody; Alpha-2,8-sialyltransferase 8B antibody; EC 2.4.99.- antibody; Sialyltransferase 8B antibody; SIAT8-B antibody; Sialyltransferase St8Sia II antibody; ST8SiaII antibody; Sialyltransferase X antibody; STX antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Alpha-2,8-sialyltransferase 8B protein (24-160AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

May transfer sialic acid through alpha-2,8-linkages to the alpha-2,3-linked and alpha-2,6-linked sialic acid of N-linked oligosaccharides of glycoproteins and may be involved in PSA (polysialic acid) expression.

Gene References into Functions

The ST8SIA2 risk haplotype copy number did not show any differential effects on white matter in schizophrenia. PMID: 29353880
impairment of the regulated expression of ST8SIA2 and the resulting downstream effects on gene products by these two intronic single nucleotide polymorphism contribute to the development of these psychiatric disorders. PMID: 27565727
ST8SiaII role in the invasiveness and metastasis of small cell lung cancer cells PMID: 28004110
the relationships between psychiatric disorders and polySia and/or ST8SIA2 PMID: 27105834
Data indicate a possible role of STX polysialyltransferase (ST8SIA2) in the common susceptibility of schizophrenia and bipolar I disorder (BD-I). PMID: 26418860
Our study showed interesting sex-specific associations between ST8SIAII and schizophrenia. PMID: 24070986
the role of ST8SIA2 sequence variation affecting polysialic acid-NCAM formation in 48 Caucasian cases with bipolar disorder PMID: 24651862
translational modification of the neural cell adhesion molecule NCAM and the polysialyltransferase ST8SiaII in mammalian semen involves polysialic acid PMID: 23671285
Expression of ST8SIA2 in omental fat at baseline was significantly associated with weight loss after Roux-en-Y gastric bypass. PMID: 23643386
that variation the ST8SIA2 gene is associated with increased risk to mental illness PMID: 22693595
NCAM and polySia are expressed and developmentally regulated in chick corneas. Both membrane-associated and soluble NCAM isoforms are expressed in chick corneas. PMID: 22281821
ST8SIA2 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells. PMID: 21555518
STX(G421A) shows a dramatic decrease in polySia synthetic activity on NCAM, whereas STX(C621G) does not; polySia shows a dopamine (DA) binding activity PMID: 21464126
This study provided that ST8SIA2 are associated with Bipolar I in the Han Chinese population. PMID: 20386566
SIAT8B has a role in neural development and sialic acid synthesis on NCAM PMID: 12138100
SIAT8B gene is involved in schizophrenia in the Japanese. PMID: 16229822

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Subcellular Location

Golgi apparatus membrane; Single-pass type II membrane protein.

Protein Families

Glycosyltransferase 29 family

Tissue Specificity

Highly expressed in fetal brain, kidney and heart and to a much lesser extent in adult heart and thymus.

Database Links

HGNC: 10870

OMIM: 602546

KEGG: hsa:8128

STRING: 9606.ENSP00000268164

UniGene: Hs.302341

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Protein Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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