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STAC3 Antibody, HRP conjugated

Datasheet
Code CSB-PA839373LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) STAC3 Polyclonal antibody
Uniprot No.
Q96MF2
Target Names
STAC3
Alternative Names
MGC2793 antibody; SH3 and cysteine rich domain 3 antibody; SH3 and cysteine rich domain-containing protein 3 antibody; SH3 and cysteine-rich domain-containing protein 3 antibody; stac3 antibody; STAC3_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human SH3 and cysteine-rich domain-containing protein 3 protein (1-253AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
ELISA Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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STAC3 Antibodies

STAC3 Proteins

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Target Background

Function
Required for normal excitation-contraction coupling in skeletal muscle and for normal muscle contraction in response to membrane depolarization. Required for normal Ca(2+) release from the sarcplasmic reticulum, which ultimately leads to muscle contraction. Probably functions via its effects on muscle calcium channels. Increases CACNA1S channel activity, in addition to its role in enhancing the expression of CACNA1S at the cell membrane. Has a redundant role in promoting the expression of the calcium channel CACNA1S at the cell membrane. Slows down the inactivation rate of the calcium channel CACNA1C.
Gene References into Functions
  1. STAC3 mutation is associated with overlapping features of Carey-Fineman-Ziter syndrome and Moebius syndrome. PMID: 28777491
  2. A mutation in human STAC3 is the genetic basis of the debilitating Native American myopathy. PMID: 23736855
Involvement in disease
Native American myopathy (NAM)
Subcellular Location
Cytoplasm. Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Cell membrane, sarcolemma, T-tubule.
Database Links

HGNC: 28423

OMIM: 255995

KEGG: hsa:246329

STRING: 9606.ENSP00000329200

UniGene: Hs.417595

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