STAG1 Antibody

1. The SNP but not wild-type had profound alterations in SA-1 expression with miR-29b inhibitor. PMID: 29471289
2. Here the authors demonstrate that the most frequently mutated subunit of the cohesin complex, STAG2, displays a strong synthetic lethal interaction with its paralog STAG1. Mechanistically, STAG1 loss abrogates sister chromatid cohesion in STAG2 mutated but not in wild-type cells leading to mitotic catastrophe, defective cell division and apoptosis. PMID: 28691904
3. This first series reporting the phenotype ascribed to mutation in STAG1 highlights the importance of data sharing in the field of rare disorders. PMID: 28119487
4. Data indicate that cohesin subunit SA-1 (STAG1) is a promising therapeutic target in cancers with inactivating alterations of cohesin subunit SA-2 (STAG2). PMID: 28430577
5. There is LOH at STAG1 and STAG2 loci in oral squamous cell carcinoma (OSCC), but OSCC and NM showed similar transcriptional levels of STAG1, STAG2, and PDS5B. PMID: 27341316
6. Data support the hypothesis that CTCF and cohesin SA-1 have multiple roles in the regulation of gene expression during erythropoiesis. PMID: 27219007
7. TRF1 tethers SA1 within telomeric regions that SA1 transiently interacts with. SA1 and TRF1 together form longer DNA-DNA pairing tracts than with TRF1 alone, as revealed by atomic force microscopy imaging PMID: 27298259
8. Nuclear import and export signals of human cohesins SA1/STAG1 and SA2/STAG2 expressed in Saccharomyces cerevisiae. PMID: 22715410
9. Mutations in STAG1 is associated with acute myeloid leukemia. PMID: 24335498
10. cohesin-SA1 and cohesin-SA2 participate in the DNA damage response PMID: 24324008
11. Rad21 binds to SA proteins through two SA-binding motifs on Rad21. PMID: 23874961
12. STAG1, a novel transcriptional target for p53, mediates p53-dependent apoptosis, and might be a good candidate for next-generation gene therapy in cancer. PMID: 15361841
13. STAG1 (Scc3/SA1) subunit of cohesin interacts with the CCTC-binding factor CTCF bound to the c-myc insulator element. PMID: 18550811
14. cohesin(SA1) and cohesin(SA2) are differentially required for telomere and centromere cohesion, respectively. PMID: 19822671

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HGNC: 11354

OMIM: 604358

KEGG: hsa:10274

STRING: 9606.ENSP00000372689

UniGene: Hs.412586