STAU2 Antibody

Code CSB-PA885729ESR2HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA885729ESR2HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) STAU2 Polyclonal antibody
Uniprot No.
Target Names
STAU2
Alternative Names
39K2 antibody; 39K3 antibody; DKFZp781K0371 antibody; Double stranded RNA binding protein Staufen homolog 2 antibody; Double-stranded RNA-binding protein Staufen homolog 2 antibody; MGC119606 antibody; STAU 2 antibody; stau2 antibody; STAU2_HUMAN antibody; Staufen (Drosophila; RNA-binding protein) homolog 2 antibody; Staufen double-stranded RNA binding protein 2 antibody; Staufen homolog 2 antibody; Staufen RNA binding protein homolog 2 antibody; Staufen; RNA binding protein; homolog 2 (Drosophila) antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Double-stranded RNA-binding protein Staufen homolog 2 protein (1-100AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body.
Gene References into Functions
  1. during genotoxic stress, Stau2 is downregulated at the promoter level in an ATR- and E2F1-dependent manner, leading to increased levels of DNA damage and apoptosis. PMID: 26843428
  2. Authors establish that human Staufen-2, a host factor which is up-regulated upon HIV-1 infection, interacts with HIV-1 Rev, thereby promoting its RNA export activity and progeny virus formation. PMID: 24520823
  3. Staufen2 functions in Staufen1-mediated mRNA decay by binding to itself and its paralog and promoting UPF1 helicase but not ATPase activity. PMID: 23263869
  4. We suggest a role for Stau2 in the generation and regulation of Map1b mRNA containing granules that are required for mGluR-long-term depression PMID: 21508097
  5. Data show that Stau2 is localized to the neuronal soma and dendrites, but it does not colocalize with Stau1-containing particles. PMID: 12140260
  6. Stau1- and Stau2-mRNPs associate with distinct but overlapping sets of cellular mRNAs. PMID: 18094122

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Subcellular Location
Cytoplasm. Nucleus. Nucleus, nucleolus. Endoplasmic reticulum.
Database Links

HGNC: 11371

OMIM: 605920

KEGG: hsa:27067

STRING: 9606.ENSP00000428756

UniGene: Hs.561815

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