Product Details

Uniprot No.

Target Names

STK24

Alternative Names

epididymis secretory protein Li 95 antibody; HEL-S-95 antibody; Mammalian STE20 like protein kinase 3 antibody; Mammalian STE20-like protein kinase 3 antibody; Mammalian STE20-like protein kinase 3 C-terminal antibody; Mammalian STE20-like protein kinase 3 N-terminal antibody; Mammalian sterile 20-like 3 antibody; MST-3 antibody; MST3/C antibody; MST3/N antibody; MST3B antibody; serine threonine kinase 24 antibody; Serine/threonine kinase 24 (Ste20; yeast homolog) antibody; Serine/threonine-protein kinase 24 12 kDa subunit antibody; Serine/threonine-protein kinase 24 antibody; STE20 homolog yeast antibody; STE20 like kinase MST3 antibody; STE20-like kinase MST3 antibody; Stk24 antibody; STK24_HUMAN antibody; STK3 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthesized peptide derived from the C-terminal region of Human MST-3.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid

Tested Applications

WB, IHC, ELISA

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:100-1:300
ELISA	1:40000

Protocols

Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Related Products

Target Background

Function

Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. In association with STK26 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation. Regulates also cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve.

Gene References into Functions

High MST3 expression is associated with breast cancer. PMID: 26910843
This study demonistrated that MST3 kinase phosphorylates TAO1/2 to enable Myosin Va function in promoting spine synapse development. PMID: 25456499
This review notes that in the SOK1 and MST4 germinal center kinase III family of proteins, exon 1 encodes a 5' untranslated region, but this is not the case for MST3. PMID: 23889253
These data provide molecular understanding of the mechanism by which MO25 isoforms regulates the activity of STE20 family protein kinases. PMID: 23296203
results show that a STRADalpha-rac1-PAK1 pathway regulates cell polarity and invasion in LKB1-null cells. It also suggests that while the function of LKB1 and STRADalpha undoubtedly overlap, they may also have mutually exclusive roles PMID: 22493453
mechanism of regulation of MST3 PMID: 22229648
Striatin orchestrates the regulation of Mst3 by PP2A. PMID: 21985334
Mst3 is up-regulated and plays an important role in hypoxia-induced apoptosis of human trophoblasts. PMID: 21277991
five crystal structures of the catalytic domain of MST3 are presented, including a complex with ADP and manganese, a unique cofactor preferred by the enzyme, and a complex with adenine. PMID: 20124694
The mammalian sterile 20-like serine/threonine protein kinase 3 (Mst3) plays an essential role in the staurosporine-induced apoptosis of HeLa cells. PMID: 19782762
Proteolytic activation of Mst3 by caspases. PMID: 12107159
Mst3 contains signals which may cooperate to control the subcellular distribution of Mst3. PMID: 15304321
Activation of NDR2 is a multistep process involving phosphorylation of the hydrophobic motif site Thr444/2 by MST3. PMID: 16314523
MST3 inhibits cell migration in a fashion dependent on autophosphorylation and may regulate paxillin phosphorylation through tyrosine phosphatase PTP-PEST PMID: 17046825
study demonstrated the essential role of Mst3, a human Ste20-like protein kinase, in the oxidative stress-induced apoptosis of trophoblasts of term placenta in normal spontaneous delivery PMID: 18040775
Our results reveal that H2O2-induced MST3-mediated cell death involves suppressing both a JNK survival pathway and up-regulation of HO-1. PMID: 19604147

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Subcellular Location

Cytoplasm. Nucleus. Membrane. Note=The truncated form (MST3/N) translocates to the nucleus. Colocalizes with STK38L in the membrane.

Protein Families

Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily

Tissue Specificity

Isoform A is ubiquitous. Isoform B is expressed in brain with high expression in hippocampus and cerebral cortex.

Database Links

HGNC: 11403

OMIM: 604984

KEGG: hsa:8428

STRING: 9606.ENSP00000365730

UniGene: Hs.508514

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