STX7 Antibody

Code CSB-PA022903GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
STX7
Alternative Names
STX7; Syntaxin-7
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human STX7
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes.
Gene References into Functions
  1. Data suggest that accumulation of recycling T cell receptors at the immunological synapse is SNARE-dependent and that Stx7-mediated processing of recycling TCRs through endosomes is a prerequisite for the cytolytic function of cytotoxic T lymphocytes. PMID: 21438968
  2. data reveal the presence of syntaxin 7 in the membranes of exocytosis-prone granules and phagocytosis-related granules in human neutrophils, and therefore it might play a role in both exocytosis and phagocytosis in human neutrophils PMID: 20170677
  3. syntaxin 7 has a role in the intracellular vacuolation induced by VacA PMID: 12730232
  4. Results report that syntaxin 7, syntaxin 8, vti1b and VAMP8 physically and functionally interact with CFTR. PMID: 18570918
  5. Palmitoylation-defective syntaxin 7 is selectively retained on the plasma membrane, suggesting that palmitoylation is important for intercompartmental transport of syntaxin 7. PMID: 18980942
  6. The expression level of STX7 protein was inversely correlated to tumor stage, suggesting that decreased expression of STX7 is associated with more aggressive tumors. PMID: 19714869

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Subcellular Location
Early endosome membrane; Single-pass type IV membrane protein.
Protein Families
Syntaxin family
Tissue Specificity
Highest expression is found in placenta followed by heart, skeletal muscle, kidney and brain. Low expression is found in pancreas, lung and liver.
Database Links

HGNC: 11442

OMIM: 603217

KEGG: hsa:8417

STRING: 9606.ENSP00000356918

UniGene: Hs.593148

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