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STYX Antibody, FITC conjugated

Datasheet
Code CSB-PA851966LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) STYX Polyclonal antibody
Uniprot No.
Q8WUJ0
Target Names
STYX
Alternative Names
Protein tyrosine phosphatase like protein antibody; Protein tyrosine phosphatase-like protein antibody; Serine/threonine/tyrosine interacting protein antibody; Serine/threonine/tyrosine-interacting protein antibody; Styx antibody; STYX_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Serine/threonine/tyrosine-interacting protein (1-223AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Catalytically inactive phosphatase. Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2). By binding to the F-box of FBXW7, prevents the assembly of FBXW7 into the SCF E3 ubiquitin-protein ligase complex, and thereby inhibits degradation of its substrates. Plays a role in spermatogenesis.
Gene References into Functions
  1. The authors show that STYX binds to the F-box domain of FBXW7 and disables its recruitment into the SCF ubiquitin ligase complex. PMID: 28007894
  2. Results suggest that STYX is a pseudophosphatase that uses the 'competitor' and 'anchor' mode of action to exert its biologic roles. [review] PMID: 28408485
  3. results identify STYX as an important regulator of ERK1/2 signaling critical for cell migration PMID: 23847209
Subcellular Location
Nucleus. Cytoplasm, cytosol.
Protein Families
Protein-tyrosine phosphatase family, Non-receptor class subfamily
Database Links

HGNC: 11447

OMIM: 615814

KEGG: hsa:6815

STRING: 9606.ENSP00000346599

UniGene: Hs.364980

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