SUPT20H Antibody

Code CSB-PA394854
Size US$100
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  • Western Blot analysis of mouse-kidney cells using Antibody diluted at 1000
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Product Details

Uniprot No.
Target Names
SUPT20H
Alternative Names
AA667204 antibody; AI450544 antibody; bA421P11.4 antibody; C13 antibody; C13orf19 antibody; D3Ertd300e antibody; FA48A_HUMAN antibody; FAM48A antibody; FP757 antibody; p38-interacting protein antibody; p38IP antibody; Protein FAM48A antibody; RGD1307812 antibody; SPT20 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthetic peptide from AA range: 231-280
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Purification Method
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Form
Liquid
Tested Applications
WB,ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-10000ELISA:1:10000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail. Required for starvation-induced ATG9A trafficking during autophagy.
Gene References into Functions
  1. provide the first report that p38-p38IP is required for the Snail-induced E-cadherin down-regulation and cell invasion in HNSCC PMID: 27531877
  2. p38IP inhibits ubiquitination-induced GCN5 degradation and therefore promotes alpha-tubulin acetylation, facilitating spindle formation and G2/M progression. PMID: 24220028
  3. hSPT20 and other hSAGA subunits, together with RNA polymerase II, are specifically recruited to genes induced by endoplasmic reticulum (ER) stress. PMID: 19114550
  4. Manipulation of p38IP and p38alpha alters mAtg9 localization, suggesting p38alpha regulates, through p38IP, the starvation-induced mAtg9 trafficking to forming autophagosomes. PMID: 19893488
  5. Novel transcription factors identified in human CD34 antigen-positive hematopoietic stem cells. PMID: 12070015
  6. C13orf19 mRNA is down-regulated in matched prostate tissues compared to prostate carcinoma tissues PMID: 15978328
  7. C13orf19 is expressed independently of the androgen. No interaction between C13orf19 and p38MAPK was identified. PMID: 16685401
  8. mRNA is down-regulated in human prostate cancer, also described as C13 PMID: 11340631

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Subcellular Location
Nucleus.
Protein Families
SPT20 family
Tissue Specificity
Highly expressed in testis, moderately in brain and pituitary gland. Expressed in several fetal tissues, including lung, brain, thymus and kidney. Expression is down-regulated in malignant prostate tissues.
Database Links

HGNC: 20596

OMIM: 613417

KEGG: hsa:55578

STRING: 9606.ENSP00000218894

UniGene: Hs.435815

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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