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SYT6 Antibody, Biotin conjugated

Datasheet
Code CSB-PA716356LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SYT6 Polyclonal antibody
Uniprot No.
Q5T7P8
Target Names
SYT6
Alternative Names
Synaptotagmin 6 antibody; Synaptotagmin VI antibody; Synaptotagmin-6 antibody; Synaptotagmin6 antibody; SynaptotagminVI antibody; Syt 6 antibody; Syt VI antibody; SYT6 antibody; SYT6_HUMAN antibody; SytVI antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Synaptotagmin-6 protein (104-425AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
ELISA Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. May mediate Ca(2+)-regulation of exocytosis in acrosomal reaction in sperm.
Gene References into Functions
  1. synaptotagmin must be dephosphorylated at a specific window of time and phosphorylated synaptotagmin has an active role at early stages of the acrosomal exocytosis. PMID: 20551332
  2. Acrosomal exocytosis is regulated through the PKC-mediated phosphorylation of conserved threonines in the polybasic regions of synaptotagmin VI. PMID: 16111671
  3. SYT6 is hypermethylated in renal cell carcinoma. PMID: 18639284
Subcellular Location
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein.; [Isoform 1]: Membrane; Single-pass membrane protein.; [Isoform 2]: Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein.
Protein Families
Synaptotagmin family
Database Links

HGNC: 18638

OMIM: 607718

KEGG: hsa:148281

STRING: 9606.ENSP00000358559

UniGene: Hs.370963

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