TADA2A Antibody

Code CSB-PA004223
Size US$100
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  • Western Blot analysis of COLO205 cells using TADA2L Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
TADA2A
Alternative Names
TADA2A antibody; TADA2L antibody; KL04P antibody; Transcriptional adapter 2-alpha antibody; Transcriptional adapter 2-like antibody; ADA2-like protein antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat,Monkey
Immunogen
Synthesized peptide derived from the Internal region of Human TADA2L.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:10000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site. Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage.
Gene References into Functions
  1. results thus demonstrate that the catalytic activity of GCN5 is stimulated by subunits of the ADA2a- or ADA2b-containing HAT modules and is further increased by incorporation of the distinct HAT modules in the ATAC or SAGA holo-complexes PMID: 26468280
  2. Single nucleotide polymorphism in ADA2 gene is associated with type 1 diabetes. PMID: 25492086
  3. CCDC134 increased the PCAF-dependent K320 acetylation of p53 and p53 protein stability in the presence of hADA2a overexpression. PMID: 22644376
  4. The three-dimensional solution structure of the SWIRM domain from the human transcriptional adaptor ADA2alpha was reported. PMID: 16299514
  5. hADA2a and hADA3 as crucial cofactors of beta-catenin that are likely involved in the assembly of transactivation-competent beta-catenin complexes at Wnt target genes. PMID: 18059173

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Subcellular Location
Nucleus. Chromosome.
Tissue Specificity
Expressed in all tissues, but most abundantly in testis.
Database Links

HGNC: 11531

OMIM: 602276

KEGG: hsa:6871

STRING: 9606.ENSP00000225396

UniGene: Hs.500066

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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