TAF1B Antibody

Code CSB-PA023084GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
TAF1B
Alternative Names
TAF1B antibody; TATA box-binding protein-associated factor RNA polymerase I subunit B antibody; RNA polymerase I-specific TBP-associated factor 63 kDa antibody; TAFI63 antibody; TATA box-binding protein-associated factor 1B antibody; TBP-associated factor 1B antibody; Transcription initiation factor SL1/TIF-IB subunit B antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human TAF1B
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3.
Gene References into Functions
  1. AEP coactivator complex facilitates the initiation of RNAP2-dependent transcription via SL1 activity by loading TBP onto the TATA element. PMID: 26593443
  2. findings show that Rrn7, a subunit of the yeast Pol I core factor, and its human ortholog TAF1B are TFIIB-like factors PMID: 21921198
  3. TAF1B, a subunit of SL1, is structurally related to TFIIB/TFIIB-like proteins; SL1, essential for Pol I recruitment to rRNA gene promoter, also has an essential postpolymerase recruitment role, operating through TAF1B PMID: 21921199
  4. Identification of MARCKS, FLJ11383 and TAF1B as putative novel target genes in colorectal carcinomas with microsatellite instability. PMID: 12140758
  5. The four most frequently mutated genes in colorectal cancers with microsatellite instability were ACVR2 (92%), TAF1B (84%), ASTE1/HT001 (80%) and TGFBR2 (77%). PMID: 19503063

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Subcellular Location
Nucleus, nucleolus.
Protein Families
RRN7/TAF1B family
Database Links

HGNC: 11533

OMIM: 604904

KEGG: hsa:9014

STRING: 9606.ENSP00000263663

UniGene: Hs.584833

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