TAF1C Antibody

Code CSB-PA620884ESR1HU
Size US$166
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Image
  • Western blot
    All lanes: TAF1C antibody at 2μg/ml + 293T whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 96, 85, 59, 50, 93 kDa
    Observed band size: 96 kDa

  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA620884ESR1HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA620884ESR1HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TAF1C Polyclonal antibody
Uniprot No.
Target Names
TAF1C
Alternative Names
RNA polymerase I-specific TBP-associated factor 110 kDa antibody; SL1 antibody; Taf1c antibody; TAF1C_HUMAN antibody; TAFI110 antibody; TAFI95 antibody; TATA box binding protein associated factor 1C antibody; TATA box-binding protein-associated factor 1C antibody; TATA box-binding protein-associated factor RNA polymerase I subunit C antibody; TBP associated factor 1C antibody; TBP associated factor RNA polymerase I 95 kDa antibody; TBP associated factor; RNA polymerase I; 110-KD antibody; TBP-associated factor 1C antibody; Transcription initiation factor SL1/TIF-IB subunit C antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human TATA box-binding protein-associated factor RNA polymerase I subunit C protein (70-320AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3.
Gene References into Functions
  1. Our results indicate that TAF1C gene harboured not only somatic frameshift mutations but also the mutational ITH, which together might play a role in tumourigenesis of gastric and colorectal cancer. PMID: 25551296
  2. PTEN represses RNA Pol I transcription through a novel mechanism that involves disruption of the SL1 complex PMID: 16055704
Subcellular Location
Nucleus.
Database Links

HGNC: 11534

OMIM: 604905

KEGG: hsa:9013

STRING: 9606.ENSP00000367802

UniGene: Hs.153022

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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