TAF4B Antibody, HRP conjugated

Code CSB-PA849782LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TAF4B Polyclonal antibody
Uniprot No.
Target Names
TAF4B
Alternative Names
TAF4B antibody; TAF2C2 antibody; TAFII105 antibody; Transcription initiation factor TFIID subunit 4B antibody; Transcription initiation factor TFIID 105 kDa subunit antibody; TAF(II)105 antibody; TAFII-105 antibody; TAFII105 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Transcription initiation factor TFIID subunit 4B protein (132-244AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Cell type-specific subunit of the general transcription factor TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAF4B is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. Plays a role in spermiogenesis and oogenesis.
Gene References into Functions
  1. The existence of a highly conserved TAF4b-dependent gene regulatory network. PMID: 27341508
  2. Two candidate loci in each family and homozygous truncating mutations p.R611X in TAF4B in family 1 and p.K507Sfs*3 in ZMYND15 in family 2, were identified. PMID: 24431330
  3. We show evidence for the first time of an interdependence of TAF4b and AP-1 family members in cell type-specific promoter recognition and initiation of transcription in the context of cancer progression and EMT. PMID: 20353996
  4. histone fold domain mediated interaction enhances the DNA binding activity of each of the TAF6-TAF9 and TAF4b-TAF12 pairs and of a histone-like octamer complex composed of the four TAFs PMID: 15601843
  5. work suggests that pre-mRNA processing and post-translational modification represent two important regulatory steps for the gonad-specific functions of human TAF(II)105 PMID: 16088961
  6. Expression of the TAF4b gene is induced by MYC through a non-canonical, but not canonical, E-box which contributes to its specific response to MYC. PMID: 19020761

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Involvement in disease
Spermatogenic failure 13 (SPGF13)
Subcellular Location
Nucleus. Cytoplasm.
Protein Families
TAF4 family
Tissue Specificity
Preferentially expressed in ovarian granulosa cells (at protein level). Highly expressed in B-cells.
Database Links

HGNC: 11538

OMIM: 601689

KEGG: hsa:6875

STRING: 9606.ENSP00000269142

UniGene: Hs.369519

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