TAF7 Antibody

1. EAF1 (239-268) and TAF7 (205-235) peptide interactions were both mapped to the same groove formed by H3 and H4 helices of MED26 N-terminal domain. PMID: 28893534
2. the MED26-NTD functions as a molecular switch in the exchange of TBP-associated factor 7 (TAF7) for LEC to facilitate the transition from initiation to elongation during transcription of a subset of snRNA genes PMID: 25575120
3. These results resolve the structural organization of the TAF1-TAF7 module in TFIID and unveil a critical promoter-binding function of TAF1 in transcription regulation. PMID: 25412659
4. three CTD kinases, CDK7, CDK9, and BRD4, engage in cross-talk, modulating their subsequent C-terminal domain phosphorylation, and also phosphorylate TAF7 PMID: 23027873
5. TAF7 represents a novel c-Jun co-activator mediating activation of AP-1 target genes in response to extracellular signals PMID: 12676957
6. TAF7 has a role as a basal regulator for mammalian polyamine transport activity and MGBG-induced apoptosis PMID: 15078871
7. Functions as a check-point regulator suppressing premature transcription initiation until preinitiation complex assembly is complete. PMID: 16407123
8. These results suggest normal TBP-binding interactions--specifically recognition, stability, and conformation-are disrupted by CldAMP insertion into eukaryotic promoter sequences. PMID: 17320040
9. TAF7 interacts with the transcription factors, TFIIH and P-TEFb, resulting in the inhibition of their Pol II CTD kinase activities PMID: 18391197

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HGNC: 11541

OMIM: 600573

KEGG: hsa:6879

STRING: 9606.ENSP00000312709

UniGene: Hs.438838