TBCE Antibody

1. TBCE protein was localized in the middle region and in the tail of the sperm while in the oocyte the localization was cytosolic. PMID: 28583220
2. Although loss of function of TBCE has been documented to impact multiple developmental processes, the present findings provide evidence that hypomorphic TBCE mutations primarily drive neurodegeneration PMID: 27666369
3. Sanjad-Sakati syndrome molecular pathology has been shown to be due to mutations in the TBCE gene on chromosome 1q42-q43. PMID: 26231322
4. the role of the human TBCE and TBCB chaperones in alpha-tubulin-beta-tubulin dissociation, was investigated. PMID: 25908846
5. tudies confirmed elevated expression of three target antigens RAB38, TBCE, and DUSP12 in CML. PMID: 20103624
6. TBCE has a role in membrane trafficking in the Golgi and late endosomal compartments, tubulin assembly, and the development of the parathyroid PMID: 12389028
7. Tbce is critical for the maintenance of microtubules in mouse motor axons PMID: 12389029
8. The tubulin-specific chaperone E (Tbce) mutation described here suggests that alterations in tubulin assembly lead to retrograde degeneration of motor axons, ultimately resulting in motoneuron cell death. PMID: 12446740
9. Reviews recent findings on the molecular mechanisms of the development of the parathyroid glands, with special emphasis on the possible role of tubulin chaperone E (TBCE), implicated in the hypopathyroidism, retardation and dysmorphism (HRD) syndrome. PMID: 17008776
10. TBCE, TBCB and alpha-tubulin form a ternary complex after heterodimer dissociation. These complexes might serve to escort alpha-tubulin towards degradation or recycling, depending on the cell requirements. PMID: 17184771
11. Depletion of Op18 by means of RNA interference increased the susceptibility of tubulin to TBCE or E-like mediated disruption, while overexpressed Op18 exerted a tubulin-protective effect. PMID: 18262179
12. Study demonstrates that, unlike its counterpart TBCE, TBCB only moderately destabilizes microtubules. PMID: 19168853
13. TBCE is required for the normal development and function of neuromuscular synapses and that it promotes microtubule formation PMID: 19297412
14. TBCE may play a role in development of the anterior pituitary, corpus callosum, and white matter in addition to the parathyroid glands. PMID: 19491227

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HGNC: 11582

OMIM: 241410

KEGG: hsa:6905

STRING: 9606.ENSP00000355560

UniGene: Hs.744998