TCERG1 Antibody

Datasheet

Code	CSB-PA023291LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: 293T whole cell lysate, Rat brain tissue All lanes: TCERG1 antibody at 5.9μg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 124, 122 kDa Observed band size: 124 kDa IHC image of CSB-PA023291LA01HU diluted at 1:300 and staining in paraffin-embedded human adrenal gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) TCERG1 Polyclonal antibody

Uniprot No.

O14776

Target Names

TCERG1

Alternative Names

CA 150 antibody; Co activator of 150 kDa antibody; Coactivator of 150 kDa antibody; MGC133200 antibody; TAF 2S antibody; TAF2S antibody; TATA box binding protein (TBP) associated factor RNA polymerase II S 150kD antibody; TATA box binding protein associated factor 2S antibody; TATA box binding protein associated factor RNA polymerase II S 150kD antibody; TATA box-binding protein-associated factor 2S antibody; TBP-associated factor, RNA polymerase II, 150-kD antibody; TCERG 1 antibody; TCERG1 antibody; TCRG1_HUMAN antibody; Transcription elongation regulator 1 antibody; Transcription factor CA 150 antibody; Transcription factor CA150 antibody; Urn1 antibody

Raised in

Rabbit

Species Reactivity

Human, Rat

Immunogen

Recombinant Human Transcription elongation regulator 1 protein (782-896AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The TCERG1 Antibody (Product code: CSB-PA023291LA01HU) is Non-conjugated. For TCERG1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA023291LB01HU	TCERG1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA023291LC01HU	TCERG1 Antibody, FITC conjugated
Biotin	CSB-PA023291LD01HU	TCERG1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:200-1:500

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter.

Gene References into Functions

TCERG1 affects expression of multiple mRNAs involved in neuron projection development. PMID: 27844289
The QA repeat domain of TCERG1 is required for relocalization of CEBPalpha. PMID: 26264132
TCERG1 binds independently to elongation and splicing complexes, thus performing their coupling by transient interactions rather than by stable association with one or the other complexes. PMID: 26873599
TCERG1 sensitizes a cell to apoptotic agents, thus promoting apoptosis by regulating the alternative splicing of both the Bcl-x and Fas/CD95 genes. PMID: 26462236
This study reveals that TCERG1 regulates HIV-1 transcriptional elongation by increasing the elongation rate of RNAPII and phosphorylation of Ser 2 within the carboxyl-terminal domain. PMID: 24165037
Specific interaction of the transcription elongation regulator TCERG1 with RNA polymerase II requires simultaneous phosphorylation at Ser2, Ser5, and Ser7 within the carboxyl-terminal domain repeat. PMID: 23436654
The FF4 and FF5 domains of transcription elongation regulator 1 (TCERG1) target proteins to the periphery of speckles. PMID: 22453921
We propose that TCERG1 modulates the elongation rate of RNAPII to relieve pausing, thereby activating the proapoptotic Bcl-x(S) 5' splice site. PMID: 22158966
TCERG1 can inhibit C/EBPalpha activity regardless of the latter's location in the nucleus PMID: 21503969
mutation of the SUMO acceptor lysine residues enhanced TCERG1 transcriptional activity, indicating that SUMO modification negatively regulates TCERG1 transcriptional activity PMID: 20215116
Specific alleles in GluR6 and CA150 locus were only observed in HD patients. PMID: 12821179
Results suggest an essential role of WW/FF domain-containing factors such as FBP11 and CA150 in pre-mRNA splicing that likely occurs in concert with transcription in vivo. PMID: 15456888
CA150 is a co-repressor of C/EBP proteins and provides a possible mechanism for how C/EBPalpha can repress transcription of specific genes PMID: 16644732
Sequences located at both the amino and carboxyl regions of CA150 are required to assemble transcription/splicing complexes, which may be involved in the coupling of those processes. PMID: 16782886
GRIN2A and TCERG1 may show true association with residual age of onset for Huntington's disease in genetic association tests in 443 affected people from a large set of kindreds from Venezuela. PMID: 17018562
The interferon consensus sequence-binding protein (ICSBP/IRF8) represses PTPN13 gene transcription in differentiating myeloid cells PMID: 18187414
Data provide the first crystal structure of an FF domain and insights into the tandem nature of the FF domains and suggest that, in addition to protein binding, FF domains might be involved in DNA binding. PMID: 19660470
Data gave a model for FF domain organization within tandem arrays suggests a general mechanism by which individual FF domains can manoeuvre to achieve optimal recognition of flexible binding partners, such as the intrinsically-disordered phosphoCTD PMID: 19715701

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Subcellular Location

Nucleus.

Tissue Specificity

Detected in brain neurons.

Database Links

HGNC: 15630

OMIM: 605409

KEGG: hsa:10915

STRING: 9606.ENSP00000296702

UniGene: Hs.443465

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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