TCTN1 Antibody

Datasheet

Code	CSB-PA023338GA01HU
Size	$600
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Product Details
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Target Background

Product Details

Uniprot No.

Q2MV58

Target Names

TCTN1

Alternative Names

JBTS13 antibody; TCTN1 antibody; TECT1 antibody; TECT1_HUMAN antibody; Tectonic family member 1 antibody; Tectonic-1 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human TCTN1

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB,IF

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Regulator of Hedgehog (Hh), required for both activation and inhibition of the Hh pathway in the patterning of the neural tube. During neural tube development, it is required for formation of the most ventral cell types and for full Hh pathway activation. Functions in Hh signal transduction to fully activate the pathway in the presence of high Hh levels and to repress the pathway in the absence of Hh signals. Modulates Hh signal transduction downstream of SMO and RAB23.

Gene References into Functions

we describe the phenotype of a patient with Varadi syndrome who is homozygous for a previously reported mutation in TCTN1 (NM_001082538.2:c.342-2A>G, p.Gly115Lysfs*8) and suggest that allelic disorders linked to TCTN1 include Varadi syndrome, in addition to Joubert syndrome and Meckel-Gruber syndrome. PMID: 28631893
Flow cytometry analysis showed that depletion of TCTN1 could cause cell cycle arrest at the G2/M phase. This indicates that TCTN1 may be crucial for CRC cell growth. PMID: 28123172
High TCTN1 expression is associated with Pancreatic Cancer. PMID: 26844847
These findings confirmed the direct association between the TCTN1 gene and prostate cancer growth in vitro. PMID: 26310786
These data suggest TCTN1 is essential for glioma cell viability, and dysregulation of TCTN1 may play a key role in glioma tumorigenesis. PMID: 25737023
TCTN1 may serve as a novel prognostic factor and a potential therapeutic target for glioblastoma. PMID: 25304031
Mutations in Tctn1 is associated with ciliopathies. PMID: 21725307

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Involvement in disease

Joubert syndrome 13 (JBTS13)

Subcellular Location

Cytoplasm, cytoskeleton, cilium basal body. Secreted.

Protein Families

Tectonic family

Database Links

HGNC: 26113

OMIM: 609863

KEGG: hsa:79600

STRING: 9606.ENSP00000380779

UniGene: Hs.211511

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Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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