TEFM Antibody

Code CSB-PA857011LA01HU
Size US$166
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Image
  • IHC image of CSB-PA857011LA01HU diluted at 1:400 and staining in paraffin-embedded human lymph node tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TEFM Polyclonal antibody
Uniprot No.
Target Names
TEFM
Alternative Names
TEFM antibody; C17orf42 antibody; Transcription elongation factor antibody; mitochondrial antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Transcription elongation factor, mitochondrial protein (36-165AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The TEFM Antibody (Product code: CSB-PA857011LA01HU) is Non-conjugated. For TEFM Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA857011LB01HU TEFM Antibody, HRP conjugated ELISA
FITC CSB-PA857011LC01HU TEFM Antibody, FITC conjugated
Biotin CSB-PA857011LD01HU TEFM Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:200-1:500
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery.
Gene References into Functions
  1. Data provide insights into target specificity of TEFM and mechanisms by which it regulates the switch between transcription and replication of mitochondrial DNA. PMID: 29033127
  2. Data indicate transcription elongation factor (TEFM) as an essential component of the mitochondrial transcription machinery. PMID: 25690892
  3. study found interaction of TEFM with mitochondrial RNA polymerase and nascent transcript prevents generation of replication primers and increases transcription processivity and serves as a molecular switch between replication and transcription, which appear to be mutually exclusive processes in mitochondria PMID: 25635099
  4. The TEFM protein is proposed to be a critical component of the transcription apparatus of human mitochondria. PMID: 21278163
Subcellular Location
Mitochondrion matrix. Mitochondrion matrix, mitochondrion nucleoid.
Protein Families
TEFM family
Database Links

HGNC: 26223

OMIM: 616422

KEGG: hsa:79736

UniGene: Hs.317340

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