TEX14 Antibody

Code CSB-PA023405GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
TEX14
Alternative Names
TEX14 antibody; SGK307 antibody; Inactive serine/threonine-protein kinase TEX14 antibody; Protein kinase-like protein SgK307 antibody; Sugen kinase 307 antibody; Testis-expressed sequence 14 antibody; Testis-expressed sequence 14 protein antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Human TEX14
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has no protein kinase activity in vitro.
Gene References into Functions
  1. Tex14 is an important mediator of kinetochore structure and function and the fidelity of chromosome separation. PMID: 22405274
  2. TEX14 prevents the completion of cytokinesis by altering the destiny of CEP55 from a nidus for abscission to an integral component of the intercellular bridge. PMID: 20176808
  3. TEX14, also known as SgK307, contains a variant and probably inactive protein kinase domain and N-terminal ankyrin repeats. PMID: 12471243
  4. TEX14 is specifically expressed in testis PMID: 11279525
Involvement in disease
Spermatogenic failure 23 (SPGF23)
Subcellular Location
Cytoplasm. Midbody. Chromosome, centromere, kinetochore.
Protein Families
Protein kinase superfamily
Tissue Specificity
Expression restricted to testis.
Database Links

HGNC: 11737

OMIM: 605792

KEGG: hsa:56155

STRING: 9606.ENSP00000240361

UniGene: Hs.390221

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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