TFB1M Antibody, Biotin conjugated

1. Loss of TFB1M results in mitochondrial dysfunction that leads to impaired insulin secretion and diabetes. PMID: 24916378
2. Deficiency in TFB1M and impaired mitochondrial function contribute to the pathogenesis of type 2 diabetes. PMID: 21195351
3. The mRNA levels of TFB1M and TFB2M are influenced by endurance training PMID: 19681768
4. This transcription factor activates transcription of human mitochondrial DNA. PMID: 12068295
5. Human mitochondrial transcription factor B1 methylates ribosomal RNA at a conserved stem-loop PMID: 12496758
6. TFB1 interacts with the C-terminal activation region of h-mtTFA and stimulates transcription independently of its RNA methyltransferase activity PMID: 12897151
7. TFB1M is a nuclear-encoded modifier gene for phenotypic expression of the deafness-associated homoplasmic A1555G mutation in the mitochondrial 12S rRNA gene. PMID: 15110318
8. Distinct, but possibly coordinated functions of mtTFB1 and mtTFB2 in mitochondrial gene expression and biogenesis. PMID: 17557812
9. This study suggested that DNA variants in TFB1M did not contribute to the risk for parkinson disease. PMID: 18980857
10. determined the variation in the TFAM, TFB1M, and TFB2M genes in cardiac hypertrophy PMID: 19096125
11. rRNA methyltransferase activity is necessary for induction of mitochondrial biogenesis by TFB1M, but not TFB2M. PMID: 19417006

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HGNC: 17037

OMIM: 607033

KEGG: hsa:51106

STRING: 9606.ENSP00000356134

UniGene: Hs.279908