TGOLN2 Antibody

Code CSB-PA023468GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
TGOLN2
Alternative Names
TGOLN2; TGN46; TGN51; Trans-Golgi network integral membrane protein 2; Trans-Golgi network glycoprotein 46; TGN38 homolog; hTGN46; Trans-Golgi network glycoprotein 48; hTGN48; Trans-Golgi network glycoprotein 51; hTGN51; Trans-Golgi network protein 2
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Human TGOLN2,TGN46
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May be involved in regulating membrane traffic to and from trans-Golgi network.
Gene References into Functions
  1. These results indicate that hepatitis E virus (HEV)forms membrane-associated particles in the cytoplasm, and that the released HEV particles with a lipid membrane retain the antigenicity of TGOLN2 on their surface. PMID: 24221250
  2. These analyses do not provide support for the hypothesis that common genetic variation in TGOLN2 contributes significantly to the risk for attempted suicide in subjects with major mood disorders. PMID: 20468057
  3. These data have identified different itineraries for the retrograde transport of Shiga toxin and TGN38 and distinct retromer components that regulate the transport of these cargos. PMID: 20138391
  4. FXIII-A associated with podosomes & other structures adjacent to the plasma membrane, containing TGN46 & GM130 but not protein disulphide isomerase. FXIII-A was present in GM130-positive intracellular vesicles that could mediate its transport. PMID: 20086247
Subcellular Location
Cell membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Note=Primarily in trans-Golgi network. Cycles between the trans-Golgi network and the cell surface returning via endosomes.
Tissue Specificity
Isoform TGN46 is widely expressed. Isoform TGN51 is more abundant in fetal lung and kidney. Isoform TGN48 is barely expressed in embryonic kidney and promyelocytic cells.
Database Links

HGNC: 15450

OMIM: 603062

KEGG: hsa:10618

STRING: 9606.ENSP00000386443

UniGene: Hs.593382

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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