THEMIS2 Antibody, Biotin conjugated

1. SNP rs1467465 of the human gene icb-1 might affect susceptibility to ovarian cancer. PMID: 24826199
2. Loss of icb-1 expression accelerated proliferation of SK-OV-3, OVCAR-3 and OAW-42 cells and led to upregulation of ovarian cancer biomarkers like KLK10 and CLDN16. PMID: 23474491
3. Data of this study suggest that icb-1 might exert a tumor-suppressor function in breast cancer and that its loss might confer relative resistance of breast cancer cells to apoptotic drugs. PMID: 22565810
4. Themis2 and Themis1 exhibit the same potential to restore T cell development and T cell receptor-mediated signaling in Themis1-deficient mice. PMID: 22732588
5. These findings together with the observed co-expression of icb-1 with E-cadherin in breast cancer samples support an important role of the icb-1 gene in cancer cell differentiation. PMID: 21455565
6. Data show that a highly significant positive correlation of icb-1 transcript levels with c-erbB2 (HER2) expression (p <.0001). PMID: 20569072
7. Identification of ICB-1 as a new player in endocrine-related cancer. PMID: 19942713
8. Increased icb-1 mRNA levels could be observed both in monocytic and granulocytic differentiation in maturing HL-60 cells. PMID: 12191572
9. The novel interferon-gamma inducible gene icb-1 is identified and its effects on the response of ovarian cancer cells to interferon-gamma are described PMID: 16219472
10. Data suggest that SNP rs1467465 of human gene icb-1 might affect breast cancer susceptibility. PMID: 19308812

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HGNC: 16839

OMIM: 617856

KEGG: hsa:9473

STRING: 9606.ENSP00000363031

UniGene: Hs.10649