TLE3 Antibody

1. Patients with TLE3-negative tumors displayed poorer outcomes regarding progression-free survival than patients with TLE3-positive tumors when prognosis within the group of patients with triple-negative breast cancer (TNBC) lesions was analyzed. In contrast, no such difference in prognosis was found in a comparison of TLE-3 positive/negative patients in the group of all patients. PMID: 28859615
2. Wnt signaling pathway inactivates the TLE3 co-repressor via HECT E3 ubiquitin ligase Hyd/UBR5 ubiquitination. PMID: 28689657
3. Data indicate that microRNA miR-744 activated Wnt/beta-catenin pathway by targeting multiple negative regulators of Wnt/beta-catenin signaling, including SFRP1, GSK3beta, TLE3 and NKD1, and that NKD1 is a major functional target of miR-744. PMID: 28107193
4. Increased adipose tissue (AT) TLE3 in subjects with type 2 diabetes and in AT from high fat diet and PPARgamma knockout mice suggest that TLE3 may play an adaptive regulatory role that improves AT function under decreased PPARgamma expression PMID: 25249007
5. induction of TLE3 by Wnt signaling is part of a negative feedback loop active during osteoblast differentiation PMID: 24444608
6. High TLE3 expression predicts a favorable response to taxane containing chemotherapy regimens in ovarian carcinoma. PMID: 22194527
7. A lack of TLE3 expression in cutaneous angiosarcoma may reflect differing pathogenesis. PMID: 22050093
8. results demonstrate that different isoforms of TLE genes are commonly transcribed in human tissues and suggest that TLE3 could be involved in prostate cancer development PMID: 18273443

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HGNC: 11839

OMIM: 600190

KEGG: hsa:7090

STRING: 9606.ENSP00000452871

UniGene: Hs.287362