TM4SF5 Antibody

1. These results suggest that our novel antibody can be used to detect endogenous and recombinant TM4SF5, and that TM4SF5 may be a possible marker for the poor prognosis of patients with colorectal cancer PMID: 29749436
2. The review discusses the antifibrotic strategies that target TM4SF5 and its associated protein networks that regulate the intracellular signaling necessary for fibrotic functions of hepatocytes. PMID: 28458469
3. Replacement of the transmembrane 4 L six family protein TM4SF1 or TM4SF4 C-terminus with that of TM4SF5 increased spheroids growth, transwell migration, and invasive dissemination from spheroids in 3D collagen gels. PMID: 28129652
4. TM4SF5-miR-4697-3P- CTD-2354A18.1 may play a key role in the pathogenesis of gastric cancer PMID: 26531872
5. TM4SF5-positive tumors exhibited locally-increased CD44 expression, suggesting tumor cell differentiation PMID: 25772760
6. TM4SF5 interacted with CD151, and caused the internalization of CD63 from the cell surface. PMID: 25033048
7. promotes self-renewal and circulating tumor cell properties PMID: 25627085
8. TM4SF5-specific monoclonal antibody has a therapeutic effect against colon cancer. PMID: 25268742
9. TM4SF5 expression in SNU761 cells caused invasive extracellular matrix degradation negatively depending on IL-6/IL-6 receptor signaling. PMID: 24912675
10. Findings demonstrate that TM4SF5 directly binds to and activates FAK in an adhesion-dependent manner, to regulate cell migration and invasion in hepatocellular carcinoma. PMID: 23077174
11. TM4SF5 is positively associated with esophageal cancer invasiveness PMID: 23633159
12. results indicate that TGFbeta1- and growth factor-mediated signalling activities mediate TM4SF5 expression leading to acquisition of mesenchymal cell features, suggesting that TM4SF5 induction may be involved in the development of liver pathologies PMID: 22292774
13. Results indicate that TM4SF5-mediated epithelial-mesenchymal transition may have an important function in the gefitinib resistance of cancer cells. PMID: 22178131
14. involvement of JNKs in TM4SF5-mediated p27(Kip1) Ser10 phosphorylation and localization during epithelial-mesenchymal transition. PMID: 22014979
15. TM4SF5 expression appeared to cause loss of cell-cell adhesions via proteasome suppression and thereby proteasome inhibition PMID: 21328452
16. TM4SF5 plays a central regulatory role in a wide variety of physiological processes through cross-talk with integrins.[review] PMID: 21196261
17. Data show that TM4SF5 expression facilitated migration, invadopodia formation, MMP activation, invasion, and eventually lung metastasis in vitro and in nude mice, but suppression of TM4SF5 with its shRNA blocked the effects. PMID: 20506553
18. Data suggest that TM4SF5 accelerates G1/S phase progression with facilitated CDK4/cyclin D1 entry into the nucleus, which might be supported by TM4SF5-mediated actin reorganization through cytosolic p27Kip1 expression and Rho GTPase activity. PMID: 20399237
19. The ectopic expression of TM4SF5 in Cos7 cells reduced integrin signaling under serum-containing conditions, but increased integrin signaling upon serum-free replating on substrates. PMID: 16828471
20. observations have revealed a role for TM4SF5 in causing uncontrolled growth of human hepatocarcinoma cells through epithelial-mesenchymal transition PMID: 18357344
21. TM4SF5 in hepatocytes negatively regulates integrin alpha2 function via an interaction between the extracellular loop 2 of TM4SF5 and integrin alpha2 during cell spreading on and migration through collagen I environment PMID: 19789264

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HGNC: 11857

OMIM: 604657

KEGG: hsa:9032

STRING: 9606.ENSP00000270560

UniGene: Hs.184194