TM4SF5

TM4SF5, also known as transmembrane 4 L six family member 5, is a protein - coding gene. This protein belongs to the transmembrane 4 superfamily, also called the tetraspanin family. TM4SF5 is involved in multiple biological processes, especially cell adhesion, migration, and invasion. It exerts its effects through the regulation of downstream signaling pathways, such as the PI3K/AKT pathway.
Aberrant expression of TM4SF5 has been associated with various diseases, particularly cancer. High levels of this protein often lead to tumor progression and metastasis. In terms of drug development, some pre - clinical studies are exploring inhibitors targeting TM4SF5 to block its function, aiming to provide new strategies for cancer treatment.