TMEM108 Antibody

Code CSB-PA023677GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
TMEM108
Alternative Names
TMEM108 antibody; KIAA1690 antibody; RTLN antibody; UNQ1875/PRO4318 antibody; Transmembrane protein 108 antibody; Retrolinkin antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Human TMEM108
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Transmembrane protein required for proper cognitive functions. Involved in the development of dentate gyrus (DG) neuron circuitry, is necessary for AMPA receptors surface expression and proper excitatory postsynaptic currents of DG granule neurons. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Through the interaction with DST, mediates the docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport. In hippocampal neurons, required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 and recruits the WAVE1 complex to facilitate actin-dependent BDNF:NTRK2 early endocytic trafficking and mediate signaling from early endosomes.
Subcellular Location
Membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic density. Endosome membrane. Cell projection, axon. Cell projection, dendrite. Early endosome.
Database Links

HGNC: 28451

OMIM: 617361

KEGG: hsa:66000

STRING: 9606.ENSP00000324651

UniGene: Hs.191616

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