TMEM38B Antibody

Code CSB-PA878900LA01HU
Size US$166
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  • Western blot
    All lanes: TMEM38B antibody at 1.5μg/ml
    Lane 1: Mouse thymus tissue
    Lane 2: Mouse liver tissue
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 33 kDa
    Observed band size: 33 kDa

  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA878900LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA878900LA01HU at dilution of 1:100

  • Immunofluorescent analysis of LO2 cells using CSB-PA878900LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TMEM38B Polyclonal antibody
Uniprot No.
Target Names
TMEM38B
Alternative Names
TMEM38B; C9orf87; Trimeric intracellular cation channel type B; TRIC-B; TRICB; Transmembrane protein 38B
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human Trimeric intracellular cation channel type B protein (249-291AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The TMEM38B Antibody (Product code: CSB-PA878900LA01HU) is Non-conjugated. For TMEM38B Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA878900LB01HU TMEM38B Antibody, HRP conjugated ELISA
FITC CSB-PA878900LC01HU TMEM38B Antibody, FITC conjugated
Biotin CSB-PA878900LD01HU TMEM38B Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC, IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function
Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.
Gene References into Functions
  1. TMEM38B mutations could lead to a rare form of OI, with an autosomal recessive pattern of inheritance. We identified two novel mutations (c.455-7T>G in intron 3 and c.507G>A in exon 4) in TMEM38B in three Chinese children with OI. The two mutations created a new acceptor splice site (p.R151_G152insVL) and a novel downstream termination codon (p.W169X), respectively PMID: 26911354
  2. Absence of TMEM38B causes osteogenesis imperfecta by dysregulation of calcium flux kinetics in the endoplasmic reticulum, impacting multiple collagen-specific chaperones and modifying enzymes. PMID: 27441836
  3. A deletion mutation in TMEM38B associated with autosomal recessive osteogenesis imperfecta. PMID: 23316006
  4. TMEM38B is a novel candidate gene for autosomal recessive Osteogenesis imperfecta (OI). Future studies are needed to explore fully the contribution of this gene to autosomal recessive Osteogenesis imperfecta (OI) in other populations. PMID: 23054245
Involvement in disease
Osteogenesis imperfecta 14 (OI14)
Subcellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein Families
TMEM38 family
Database Links

HGNC: 25535

OMIM: 611236

KEGG: hsa:55151

STRING: 9606.ENSP00000363824

UniGene: Hs.411925

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