TMEM59 Antibody

Code CSB-PA023860LA01HU
Size US$166
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  • Western Blot
    Positive WB detected in: MCF-7 whole cell lysate, A549 whole cell lysate, Hela whole cell lysate
    All lanes: TMEM59 antibody at 3µg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 37 kDa
    Observed band size: 37 kDa

  • Immunofluorescent analysis of HepG2 cells using CSB-PA023860LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TMEM59 Polyclonal antibody
Uniprot No.
Target Names
TMEM59
Alternative Names
TMEM59; C1orf8; HSPC001; UNQ169/PRO195; Transmembrane protein 59; Liver membrane-bound protein
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Transmembrane protein 59 protein (59-201AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The TMEM59 Antibody (Product code: CSB-PA023860LA01HU) is Non-conjugated. For TMEM59 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA023860LB01HU TMEM59 Antibody, HRP conjugated ELISA
FITC CSB-PA023860LC01HU TMEM59 Antibody, FITC conjugated
Biotin CSB-PA023860LD01HU TMEM59 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding.
Gene References into Functions
  1. identify the single-span membrane protein TMEM59 as an interactor of FZD and LRP6 and a positive regulator of Wnt signaling. Mechanistically, TMEM59 promotes the formation of multimeric Wnt-FZD assemblies via intramembrane interactions. PMID: 29632210
  2. DCF1 subcellular localization and its function in mitochondria PMID: 29074393
  3. The TMEM59 gene identified from our discovery approach was recently implicated in amyloid-beta protein precursor post-translational processing, supporting a role for epigenetic change in LOAD pathology. PMID: 22451312
  4. TMEM59 affects amyloid precursor protein shedding by reducing its acccess to cellular components. PMID: 20427278
Subcellular Location
Late endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein.
Protein Families
TMEM59 family
Database Links

HGNC: 1239

KEGG: hsa:9528

STRING: 9606.ENSP00000234831

UniGene: Hs.118947

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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