May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2. Proteolytically cleaves and activates the human coronavirus 229E (HCoV-229E) spike glycoprotein which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides, cleaving Boc-Phe-Ser-Arg-4-methylcoumaryl-7-amide most efficiently and having an optimum pH of 8.6 with this substrate.
|Gene References into Functions
- High HAT expression is associated with Idiopathic pulmonary fibrosis. PMID: 29122847
- we conclude that TMPRSS11D could play a role in non-small cell lung cancer development and progression PMID: 28086212
- HAT expression may potentially be useful as a marker for clinical grading and assessment of patient prognosis in squamous cell carcinomas PMID: 26297835
- H9N2 viruses with R-S-S-R or R-S-R-R cleavage sites in hemagglutinin are activated by matriptase in addition to HAT and TMPRSS2 and, therefore, can be activated in a wide range of tissues what may affect virus spread, tissue tropism and pathogenicity. PMID: 23192872
- TMPRSS2 and HAT are expressed by important influenza and SARS-coronavirus target cells and could thus support viral spread in the human host. PMID: 22558251
- results suggest that HAI-1 functions as a physiological regulator of HAT by inhibiting its protease activity and proteolytic activation in airway epithelium.(HAT) PMID: 22023801
- HAT cleaves proMSP at the physiological activation site PMID: 22245154
- Human HAT cleaved severe acute respiratory syndrome coronavirus spike protein at R667, as determined by mutagenesis and mass spectrometry. PMID: 21994442
- HAT regulates cellular functions of human bronchial epithelial cells via activation of protease-activated receptor-2. PMID: 12630574
- HAT might promote PAR-2-mediated IL-8 production to accumulate inflammatory cells in the epidermal layer of psoriasis. PMID: 15102084
- results indicate that HAT stimulates fibroblast proliferation in bronchial airways through a PAR-2-dependent MEK-MAPK mediated pathway and that HAT is linked to airway processes involving fibroblasts PMID: 16199437
- HAT induces amphiregulin production through the PAR-2 mediated ERK pathway, and then causes amphiregulin release by a TACE-dependent mechanism PMID: 16336275
- TMPRSS2 and HAT are candidates for proteolytic activation of influenza viruses in vivo PMID: 16973594
||Cell membrane; Single-pass type II membrane protein. Note=Activated by cleavage and secreted.; [Transmembrane protease serine 11D catalytic chain]: Secreted. Note=Activated by cleavage and secreted.
||Peptidase S1 family
||Located in the cells of the submucosal serous glands of the bronchi and trachea.