TMPRSS11D Antibody

Datasheet

Code	CSB-PA262991
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA262991(TMPRSS11D Antibody) at dilution 1/35, on the right is treated with fusion protein. (Original magnification: ×200) Gel: 8%SDS-PAGE,Lysate: 40 μg,,Primary antibody: CSB-PA262991(TMPRSS11D Antibody) at dilution 1/800 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 1 minute
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

O60235

Target Names

TMPRSS11D

Alternative Names

TMPRSS11D; HAT; Transmembrane protease serine 11D; Airway trypsin-like protease

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Fusion protein of Human TMPRSS11D

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,WB,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:2000-1:5000
WB	1:500-1:2000
IHC	1:25-1:100

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2. Proteolytically cleaves and activates the human coronavirus 229E (HCoV-229E) spike glycoprotein which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides, cleaving Boc-Phe-Ser-Arg-4-methylcoumaryl-7-amide most efficiently and having an optimum pH of 8.6 with this substrate.

Gene References into Functions

High HAT expression is associated with Idiopathic pulmonary fibrosis. PMID: 29122847
we conclude that TMPRSS11D could play a role in non-small cell lung cancer development and progression PMID: 28086212
HAT expression may potentially be useful as a marker for clinical grading and assessment of patient prognosis in squamous cell carcinomas PMID: 26297835
H9N2 viruses with R-S-S-R or R-S-R-R cleavage sites in hemagglutinin are activated by matriptase in addition to HAT and TMPRSS2 and, therefore, can be activated in a wide range of tissues what may affect virus spread, tissue tropism and pathogenicity. PMID: 23192872
TMPRSS2 and HAT are expressed by important influenza and SARS-coronavirus target cells and could thus support viral spread in the human host. PMID: 22558251
results suggest that HAI-1 functions as a physiological regulator of HAT by inhibiting its protease activity and proteolytic activation in airway epithelium.(HAT) PMID: 22023801
HAT cleaves proMSP at the physiological activation site PMID: 22245154
Human HAT cleaved severe acute respiratory syndrome coronavirus spike protein at R667, as determined by mutagenesis and mass spectrometry. PMID: 21994442
HAT regulates cellular functions of human bronchial epithelial cells via activation of protease-activated receptor-2. PMID: 12630574
HAT might promote PAR-2-mediated IL-8 production to accumulate inflammatory cells in the epidermal layer of psoriasis. PMID: 15102084
results indicate that HAT stimulates fibroblast proliferation in bronchial airways through a PAR-2-dependent MEK-MAPK mediated pathway and that HAT is linked to airway processes involving fibroblasts PMID: 16199437
HAT induces amphiregulin production through the PAR-2 mediated ERK pathway, and then causes amphiregulin release by a TACE-dependent mechanism PMID: 16336275
TMPRSS2 and HAT are candidates for proteolytic activation of influenza viruses in vivo PMID: 16973594

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Subcellular Location

Cell membrane; Single-pass type II membrane protein. Note=Activated by cleavage and secreted.; [Transmembrane protease serine 11D catalytic chain]: Secreted. Note=Activated by cleavage and secreted.

Protein Families

Peptidase S1 family

Tissue Specificity

Located in the cells of the submucosal serous glands of the bronchi and trachea.

Database Links

HGNC: 24059

OMIM: 605369

KEGG: hsa:9407

STRING: 9606.ENSP00000283916

UniGene: Hs.132195

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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