TNFAIP8L3 Antibody

Datasheet

Code	CSB-PA115238
Size	US$100
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Image	Western Blot analysis of 1,293T 2,mouse-brain cells using primary antibody diluted at 1:1000(4°C overnight). Secondary antibody:Goat Anti-rabbit IgG IRDye 800( diluted at 1:5000, 25°C, 1 hour)
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Product Details
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Target Background

Product Details

Uniprot No.

Q5GJ75

Target Names

TNFAIP8L3

Alternative Names

TNFAIP8L3 antibody; TIPE3 antibody; Tumor necrosis factor alpha-induced protein 8-like protein 3 antibody; TNF alpha-induced protein 8-like protein 3 antibody; TNFAIP8-like protein 3 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthesized peptide derived from Human TNFAIP8L3. at AA range: 15-45

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid

Tested Applications

WB,ELISA

Recommended Dilution

Application	Recommended Dilution
WB	1:500-2000
ELISA	1:10000-20000

Protocols

Western Blotting(WB) Protocol
ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Acts as a lipid transfer protein. Preferentially captures and shuttles two lipid second messengers, i.e., phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate and increases their levels in the plasma membrane. Additionally, may also function as a lipid-presenting protein to enhance the activity of the PI3K-AKT and MEK-ERK pathways. May act as a regulator of tumorigenesis through its activation of phospholipid signaling.

Gene References into Functions

In addition to replicating a previously identified genome-wide significant locus for corneal astigmatism near the PDGFRA gene, gene-based analysis identified three novel candidate genes, CLDN7, ACP2, and TNFAIP8L3, that warrant further investigation to understand their role in the pathogenesis of corneal astigmatism. (Meta-analysis) PMID: 29422769
TIPE3 downregulation correlates with its CpG island hypermethylation in several solid cancers. TIPE3 acts as a tumor suppressor in nasopharyngeal carcinoma (NPC), providing a further insight into NPC progression and representing a potential prognostic biomarker for NPC PMID: 30217224
High TIPE3 expression in the plasma membrane is associated with non-small-cell lung cancer. PMID: 29510688
TIPE3 protein was upregulated in breast cancer tissues and positively correlated to invasion and metastasis of human breast cancer cells by activating AKT and NF-kappaB signaling pathways. PMID: 28388580
Further MD simulations confirmed the dynamic stability of these lipids in the TH domain. This computational analysis thus provides insight into the binding mode of phospholipids in the TH domain of the TIPE family of proteins. PMID: 27783229
TIPE3 protein is highly expressed in most human carcinoma cell lines. These results suggest that TIPE3 may play important roles in carcinogenesis and cell secretion. PMID: 25479791
human cancers have markedly upregulated TIPE3 expression. Knocking out TIPE3 diminishes tumorigenesis, whereas enforced TIPE3 expression enhances it in vivo PMID: 25242044

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Subcellular Location

Cytoplasm. Cell membrane.

Protein Families

TNFAIP8 family

Tissue Specificity

Widely expressed (at protein level). Highly expressed in most carcinoma cell lines.

Database Links

HGNC: 20620

OMIM: 616438

KEGG: hsa:388121

UniGene: Hs.306343

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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