TNIP2 Antibody

1. RelAp43 interacts with the p105-ABIN2-TPL2 complex and we observe a strong perturbation of this complex in presence of M protein. PMID: 29084252
2. Study reports the crystal structure of hABIN2 in complex with linear triubiquitin, which shows the ubiquitins with M1-linkage could form a right-handed helical trimer when bridging two hABIN2 dimers, and thus allow the assembly of a higher-order signaling complex with A20. PMID: 27916521
3. Findings suggest an expanded role for the NF-kappaB network hub protein TNIP2 and reveals an association between TNIP2 and YLPM1, TNIP2 and ESCRT-I, together with many RNA processing proteins and a distinct set of mRNAs. PMID: 27609421
4. miR-1180 might act as a tumor promoter by targeting TNIP2 during development of hepatocellular carcinoma. PMID: 27044843
5. ABIN-2 acts as a positive regulator of NF-kappaB-dependent transcription by activating IKKalpha. PMID: 21784860
6. A20, ABIN-1/2, and CARD11 mutations have prognostic value in gastrointestinal diffuse large B-cell lymphoma PMID: 21266526
7. transcription repressed by promyelocytic leukemia protein expression PMID: 12080044
8. FLIP1 has a role in the regulation of NF-kappaB activity related to the role of LKB1 in tumor suppression PMID: 12595760
9. Endothelial tyrosine kinase Tie2 interacts with ABIN-2. PMID: 12609966
10. ABIN-2 exerts unexpected function in mediating transcriptional coactivation. PMID: 12753905
11. ABIN-2 was found to inhibit endothelial apoptosis and rescue cells from death following growth factor deprivation. Deletion of the carboxy-terminus of ABIN-2 removed its ability to inhibit apoptosis. PMID: 12933576
12. optimal TPL-2 stability in vivo requires interaction with ABIN-2 as well as p105 PMID: 15169888
13. ABIN-2 may function as a negative regulator that downregulates NF-kappaB activation during liver regeneration PMID: 16480954
14. Thus, CIH-mediated NF-kappaB activation may be a molecular mechanism linking OSA and cardiovascular pathologies seen in OSA patients. PMID: 16554025
15. Thus the present results showed a correlation between NF-kappaB activation and the repair of sublethal damage in split-dose irradiation. PMID: 17038805
16. role for an ABIN-sensitive non-classical NF-kappaB signalling pathway in the proliferation of EGFR-overexpressing tumour cells. PMID: 18622428
17. This review defines ABIN-2 based on three different parameters: ability to bind A20; ability to inhibit NF-kappaB activation upon overexpression; the presence of specific short amino acid regions of strong homology, designated ABIN homology domains. PMID: 19464428

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HGNC: 19118

OMIM: 610669

KEGG: hsa:79155

STRING: 9606.ENSP00000321203

UniGene: Hs.368551