TNIP2 Antibody

Datasheet

Code	CSB-PA713993
Size	US$100
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Image	Immunohistochemical analysis of paraffin-embedded human-cervical-cancer, antibody was diluted at 1:200 Immunohistochemical analysis of paraffin-embedded human-cervical-cancer, antibody was diluted at 1:200 Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:200 Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:200
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q8NFZ5

Target Names

TNIP2

Alternative Names

A20 binding inhibitor of NF kappaB activation 2 antibody; A20-binding inhibitor of NF-kappa-B activation 2 antibody; ABIN 2 antibody; ABIN-2 antibody; Fetal liver LKB1-interacting protein antibody; FLIP1 antibody; KLIP antibody; LKB1 interacting protein antibody; TNFAIP3 interacting protein 2 antibody; TNFAIP3-interacting protein 2 antibody; TNIP2 antibody; TNIP2_HUMAN antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthetic peptide from Human protein at AA range: 61-110

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Purification Method

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.

Form

Liquid

Tested Applications

IHC,ELISA

Recommended Dilution

Application	Recommended Dilution
IHC	1:50-300
ELISA	1:10000-20000

Protocols

Immunohistochemistry (IHC) Protocol
ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function

Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes.

Gene References into Functions

RelAp43 interacts with the p105-ABIN2-TPL2 complex and we observe a strong perturbation of this complex in presence of M protein. PMID: 29084252
Study reports the crystal structure of hABIN2 in complex with linear triubiquitin, which shows the ubiquitins with M1-linkage could form a right-handed helical trimer when bridging two hABIN2 dimers, and thus allow the assembly of a higher-order signaling complex with A20. PMID: 27916521
Findings suggest an expanded role for the NF-kappaB network hub protein TNIP2 and reveals an association between TNIP2 and YLPM1, TNIP2 and ESCRT-I, together with many RNA processing proteins and a distinct set of mRNAs. PMID: 27609421
miR-1180 might act as a tumor promoter by targeting TNIP2 during development of hepatocellular carcinoma. PMID: 27044843
ABIN-2 acts as a positive regulator of NF-kappaB-dependent transcription by activating IKKalpha. PMID: 21784860
A20, ABIN-1/2, and CARD11 mutations have prognostic value in gastrointestinal diffuse large B-cell lymphoma PMID: 21266526
transcription repressed by promyelocytic leukemia protein expression PMID: 12080044
FLIP1 has a role in the regulation of NF-kappaB activity related to the role of LKB1 in tumor suppression PMID: 12595760
Endothelial tyrosine kinase Tie2 interacts with ABIN-2. PMID: 12609966
ABIN-2 exerts unexpected function in mediating transcriptional coactivation. PMID: 12753905
ABIN-2 was found to inhibit endothelial apoptosis and rescue cells from death following growth factor deprivation. Deletion of the carboxy-terminus of ABIN-2 removed its ability to inhibit apoptosis. PMID: 12933576
optimal TPL-2 stability in vivo requires interaction with ABIN-2 as well as p105 PMID: 15169888
ABIN-2 may function as a negative regulator that downregulates NF-kappaB activation during liver regeneration PMID: 16480954
Thus, CIH-mediated NF-kappaB activation may be a molecular mechanism linking OSA and cardiovascular pathologies seen in OSA patients. PMID: 16554025
Thus the present results showed a correlation between NF-kappaB activation and the repair of sublethal damage in split-dose irradiation. PMID: 17038805
role for an ABIN-sensitive non-classical NF-kappaB signalling pathway in the proliferation of EGFR-overexpressing tumour cells. PMID: 18622428
This review defines ABIN-2 based on three different parameters: ability to bind A20; ability to inhibit NF-kappaB activation upon overexpression; the presence of specific short amino acid regions of strong homology, designated ABIN homology domains. PMID: 19464428

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Subcellular Location

Cytoplasm. Nucleus.

Tissue Specificity

Ubiquitously expressed in all tissues examined.

Database Links

HGNC: 19118

OMIM: 610669

KEGG: hsa:79155

STRING: 9606.ENSP00000321203

UniGene: Hs.368551

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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