TNNT1 Antibody

Code CSB-PA024015GA01HU
Size US$685
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Product Details

Uniprot No. P13805
Target Names TNNT1
Alternative Names ANM antibody; MGC104241 antibody; NEM5 antibody; Skeletal antibody; Slow antibody; slow skeletal muscle antibody; Slow skeletal muscle troponin T antibody; sTnT antibody; Tnnt1 antibody; TNNT1_HUMAN antibody; TNT antibody; TnTs antibody; Troponin T antibody; Troponin T slow skeletal muscle antibody; Troponin T type 1 (skeletal slow) antibody; troponin T1 skeletal slow antibody; Troponin T1, slow skeletal type antibody
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Immunogen Human TNNT1
Immunogen Species Homo sapiens (Human)
Isotype IgG
Purification Method Antigen Affinity purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications ELISA,WB
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
(From Uniprot)
Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Gene References into Functions
  1. High TNNT1 expression is associated with breast cancer. PMID: 30031058
  2. This study describes the first TNNT1 mutation that transmits in an autosomal dominant fashion to cause nemaline myopathy. PMID: 29178646
  3. investigated the effects of one of these mutations, K247R of TnT, on the picosecond dynamics of the Tn core domain (Tn-CD), consisting of TnC, TnI and TnT2 (183-288 residues of TnT), by carrying out the quasielastic neutron scattering measurements on the reconstituted Tn-CD containing either the wild-type TnT2 (wtTn-CD) or the mutant TnT2 (K247R-Tn-CD) in the absence and presence of Ca(2+) PMID: 28923663
  4. Data suggest that mutations in troponin C (TnC, A8V) and troponin T (TnT, delta14-TnT) found in patients with hypertrophic cardiomyopathy together fully stabilize the active M state of regulated actin (the actin-tropomyosin-troponin complex). PMID: 28530094
  5. pathogenesis of TNNT1 myopathies PMID: 27429059
  6. Copeptin and troponin T measurement could potentially improve the prehospital diagnostic and prognostic classification of patients with a suspected AMI. PMID: 27903076
  7. TNNT1 genetic and epigenetic variations are associated with HDL-C levels and coronary artery disease. PMID: 26950807
  8. Three homologous genes have evolved in vertebrates to encode three muscle type-specific TnT isoforms: TNNT1 for slow skeletal muscle TnT, TNNT2 for cardiac muscle TnT, and TNNT3 for fast skeletal muscle TnT. PMID: 26774798
  9. Nemaline body myopathy Palestinian patients were found to have a novel mutation in troponin T1. PMID: 26296490
  10. troponin T and creatinine kinase isoenzyme (CK-MB) have roles in combined renal and myocardial injuries in asphyxiated infants PMID: 24625749
  11. Biopsy-proven acute and viral myocarditis is associated with elevated concentrations of hs-TnT. PMID: 24781421
  12. Troponin T1 blood levels had a positive association with increased risk for hypertrophic cardiomyopathy. PMID: 24020864
  13. TNNT1 DNA methylation levels were positively correlated with mean HDL particle size, HDL-phospholipid, HDL-apolipoprotein AI, HDL-C and TNNT1 expression levels. PMID: 23244308
  14. Human slow skeletal troponin T (HSSTnT) isoforms, despite being homologues of cardiac TnT may display distinct functional properties in muscle regulation. PMID: 22977240
  15. analysis of parameters of oxygen-dependent metabolism of neutrophils by NBT test and levels of vWF antigen in the serum can be used for predicting the risk of unfavorable outcome in patients with ACS and normal troponin T PMID: 22448368
  16. In heart failure patients with normal ejection fraction, highly sensitive troponin T and heart fatty acid binding protein are elevated independent of coronary artery disease. PMID: 21729325
  17. baseline cTnT levels are higher in patients with MPI evidence of reversible myocardial ischaemia than those without reversible ischaemia PMID: 22239123
  18. carotid-femoral pulse wave and office pulse pressure are associated with minimally elevated hsTnT levels in the elderly PMID: 21784424
  19. the hypertrophic phenotype associated with the TnT mutations can be characterized by a significant increase in disorder of rigor cross-bridges. PMID: 21683708
  20. Elevated serum troponin T levels are associated with different conditions related to the severity of hypertrophic cardiomyopathy. PMID: 21111984
  21. Cardiac troponin T and creatine kinase have roles in infarct size and left ventricular function after acute myocardial infarction PMID: 21448949
  22. The occurrence of myocardial infarction is associated with elevated troponin T levels. PMID: 19916752
  23. Among athletees, faster runners demonstrate significantly stronger cardoac TnT releases and inflammation signs. PMID: 20380359
  24. troponin-T mutations were responsible for 3% of the hypertrophic cardiomyopathy cases in our study population PMID: 20038417
  25. Troponin T may have a role in pulmonary embolism progeresion to death PMID: 19541721
  26. TNT is a biochemical marker of susceptibility to hypoxia in infants of type 1 diabetic mothers. PMID: 19690080
  27. Data suggest that inefficient incorporation into myofilament is responsible for the instability of mutant slow troponin T in Amish nemaline myopathy. PMID: 15665378
  28. Report adaptation by alternative RNA splicing of slow troponin T isoforms in type 1 but not type 2 Charcot-Marie-Tooth disease. PMID: 18579801
  29. slow TnT was encoded by two different transcripts in significantly different ratios in myotonic dystrophy type 1 and myotonic dystrophy type 2 muscles. PMID: 19326042

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Involvement in disease Nemaline myopathy 5 (NEM5)
Protein Families Troponin T family
Database Links

HGNC: 11948

OMIM: 191041

KEGG: hsa:7138

STRING: 9606.ENSP00000467176

UniGene: Hs.631558

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