TNNT2 Antibody

Code CSB-PA024016GA01HU
Size $600
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Product Details

Uniprot No. P45379
Target Names TNNT2
Alternative Names Cardiac muscle troponin T antibody; Cardiomyopathy dilated 1D (autosomal dominant) antibody; Cardiomyopathy hypertrophic 2 antibody; CMD1D antibody; CMH2 antibody; CMPD2 antibody; cTnT antibody; LVNC6 antibody; MGC3889 antibody; OTTHUMP00000033864 antibody; OTTHUMP00000033865 antibody; OTTHUMP00000033866 antibody; OTTHUMP00000033867 antibody; OTTHUMP00000033870 antibody; OTTHUMP00000218095 antibody; RCM3 antibody; TNNT 2 antibody; TNNT2 antibody; TNNT2_HUMAN antibody; TnTc antibody; Troponin T cardiac muscle antibody; Troponin T type 2 (cardiac) antibody; Troponin T type 2 cardiac antibody; Troponin T, cardiac muscle antibody; Troponin T2 cardiac antibody
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Immunogen Human TNNT2
Immunogen Species Homo sapiens (Human)
Isotype IgG
Purification Method Antigen Affinity purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications ELISA,WB,IF
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Gene References into Functions
  1. Troponin T is neither specific nor useful as cardiac biomarker for post mortem sample PMID: 30173231
  2. Cardiac troponin T is the key diagnostic marker in Non-ST elevated myocardial infarction (NSTEMI). PMID: 29619842
  3. the optimal cutoff-value of hs-TnT to improve diagnostic accuracy of acute myocardial infarction in chronic kidney disease patients, was determined. PMID: 28145489
  4. This study has confirmed the higher reference levels of hscTnT in neonates and young infants when compared with adult population PMID: 29303610
  5. The current results indicate that patients with nondipper hypertension (NDH) had higher high-sensitivity - cTnT levels than the patients with dipper hypertension. High-sensitivity -cTnT was an independent predictor of NDH and was significantly related with nondipping status. PMID: 29278556
  6. Data suggest that high sensitivity cardiac troponin (hs-cTnT) may help predict whether non-acute coronary syndrome (ACS) emergency department (ED) patients have a final non-ACS cardiac or non-cardiac/unknown origin diagnoses. PMID: 28532247
  7. Cardiac troponin T at the NMJ region contributes to NMJ functional decline with ageing mainly in the fast-twitch skeletal muscle through interfering with PKA signalling. PMID: 28419739
  8. On admission, high-sensitivity-troponin T/creatine kinase-MB ratio was significantly higher in takotsubo syndrome patients compared to myocardial infarction patients. PMID: 28595746
  9. Serum high-sensitivity cardiac troponin T (HS-cTnT) level is high and associated with carotid plaques in systemic lupus erythematous (SLE) patients. PMID: 28610589
  10. High sensitivity troponin T was detectable in over half of the congenitally corrected transposition of the great arteries population and was related to right ventricular function. PMID: 28302319
  11. In patients with perinatal asphyxia, the difference in troponin-T concentrations between moderate and severe encephalopathy was not statistically significant. Troponin-T concentration was significantly higher in babies with hypotensive shock and hepatic injury, but not acute kidney injury. PMID: 28854510
  12. Five of the 19 patients (26.3%) had either a pathogenic variant or a likely pathogenic variant in MYBPC3 (n=1), MYH7 (n=1), RYR2 (n=2), or TNNT2 (n=1). All five variants were missense variants that have been reported previously in patients with channelopathies or cardiomyopathies PMID: 28202948
  13. Plasma troponin T was not altered after stress in patients with a positive stress test or those with a negative stress test. PMID: 27364992
  14. IL-6 receptor blockade has an effect on high-sensitivity troponin T and NT-proBNP in rheumatoid arthritis PMID: 27744141
  15. An exercise-associated increase in hs-cTnT and NT-proBNP occurred in response to a 60-minute maximal swimming test that was independent of pubertal status/adolescent vs adults. The present data also suggests that baseline and postexercise hs-cTnT values are higher in male compared with female, with no sex differences in NT-proBNP values. PMID: 29173327
  16. Both continuous aerobic exercise and intermittent exercise results in increased serum levels of cardiac troponin T in sedentary men. PMID: 28096042
  17. Digenic inheritance of two novel variants in TNNT2 and MYH7 is associated with a severe form of dilated cardiomyopathy. PMID: 28642161
  18. Increased levels of preprocedural hs-cTnT are proportionally related to the risk of death and emerged as independent predictors of all-cause mortality within 1 year in stable coronary artery disease patients undergoing percutaneous coronary intervention. PMID: 27296200
  19. Among patients with chest pain and stable troponin levels, any detectable level of high-sensitivity cardiac troponin is associated with an increased risk of death and cardiovascular disease. PMID: 29073949
  20. High-sensitivity cTnT measurement increases the detection of perioperative myocardial infarction. PMID: 28719430
  21. In a heart failure cohort, high sensitivity troponin T serum levels had very significant prognostic value. PMID: 27718443
  22. Asymptomatic cTnT elevation might be strongly associated with all-cause and cardiovascular mortality in dialysis patients without diabetic nephropathy. PMID: 27178276
  23. Higher postoperative concentrations of high-sensitivity troponin T are independently associated with all-cause mortality in patients undergoing on-pump cardiac surgery. PMID: 28537984
  24. variants in TNNT2 and BAG3 are associated with a high propensity to life-threatening cardiomyopathy presenting from childhood and young adulthood. PMID: 28669108
  25. Binding of the MBNL zinc fingers to cardiac troponin T pre-mRNA is specific and relatively simple, unlike the complex multiple dimer-trimer stoichiometries postulated in some previous studies. PMID: 28718627
  26. The measurement of high-sensitivity cardiac troponin T plasma concentration within large nationally-representative surveys such as the Health Survey for England is feasible. PMID: 28141863
  27. Data suggest that the tropomyosin overlap region structure and function are affected differentially by a point mutation in cardiac tropomyosin (TPM1, D230N) that is associated with dilated cardiomyopathy as compared to a point mutation in cardiac troponin T (TNNT2, R92L) that is associated with hypertrophic cardiomyopathy. PMID: 28603979
  28. High T2-weighted signal intensity on cine MRI is associated with elevated troponin T in hypertrophic cardiomyopathy. PMID: 27506680
  29. The high negative predictive value of preoperative hs-cTnT and NT-proBNP suggest usefulness as a "rule-out" test to confirm low risk of postoperative Myocardial Infarction PMID: 28002165
  30. Generated is a gene-targeted knock-in murine model of the autosomal dominant Arg141Trp (R141W) mutation in human Tnnt2. Tnnt2 R141W mutation causes a Ca2+ desensitization and mice adapt by increasing Ca2+-transient amplitudes, which impairs Ca2+ handling dynamics, metabolism and responses to beta-adrenergic activation. PMID: 27936050
  31. A myosin activator improves actin assembly and sarcomere function of human-induced pluripotent stem cell-derived cardiomyocytes with a troponin T point mutation. PMID: 27199119
  32. Our study supports that mutations in MYH7 and MYBPC3 should be the first focus of moleculargenetic analysis in HCM, and that mutations in TNNT2 have a low prevalence in Brazilian population. All mutations detected were missense mutations, whereas two mutations in MYH7 had not been described before. PMID: 27737317
  33. Dyrk1A modulates SRp55-promoted cTnT exon 5 inclusion PMID: 27049307
  34. Our results suggest that multiple enzymes are involved in cTnT degradation, and that thrombin plays an important role. PMID: 27816455
  35. In patients with clinically stable angina pectoris, slightly elevated hs-cTnT levels may indicate the presence of complex coronary artery disease. PMID: 25964074
  36. TNNT2 gene mutation is associated with Early-Onset Hypertrophic Cardiomyopathy. PMID: 27483260
  37. The results showed that MYBPC3 25-bp deletion polymorphism was significantly associated with elevated risk of left ventricular dysfunction (LVD), while TTN 18 bp I/D, TNNT2 5 bp I/D and myospryn K2906N polymorphisms did not show any significant association with LVD. PMID: 27350668
  38. A novel heterozygous mutation (MYH7, p.Asn885Thr), and a variant of uncertain significance (TNNT2, p.Arg296His) were identified in 2 patients with familial hypertrophic cardiomyopathy. PMID: 27082122
  39. Discordant elevation of cTnT in the presence of normal CK plasma levels on admission is associated with increased mortality in STEMI patients undergoing primary PCI. PMID: 26563201
  40. High cardiac troponin T expression is associated with heart diseases. PMID: 26975902
  41. The results presented here have detected important prognostic differences between patients with 1 of the TNNT2 mutations (Arg92Gln) and those with the 5 other TNNT2 mutations. Carriers of the Arg92Gln mutation developed hypertrophic or dilated cardiomyopathy and had a significantly worse prognosis than those with other mutations in TNNT2. PMID: 26507537
  42. No adverse clinical events or functional changes of the device were noted, even in those with increases in cTnT. PMID: 26489609
  43. TNNT2 TNNT2 PMID: 27363271
  44. Segmental plaque volume and presence of virtual histology derived thin-cap fibroatheroma lesions are associated with higher circulating hsTnT concentrations in stable coronary artery disease patients. PMID: 26917225
  45. High-sensitivity cardiac troponin T could be used as an early biomarker for the risk stratification of patients with type-A acute aortic dissection. PMID: 26916429
  46. An association between elevated troponin levels and increased mortality was found in critically ill patients. PMID: 26425879
  47. For patients older than 65 years of age, applications of age-specific troponin T level cut-offs resulted in a decrease in acute myocardial infarction in the entire cohort. PMID: 26878470
  48. Data show that high-sensitivity cardiac troponin T (hs-cTnT) was detected in 244 (87.1%) type 2 diabetes mellitus patients. PMID: 26823030
  49. sensitivity and specificity of cardiac specific troponin T levels in detecting cardiac damage are much higher according to telecardiography and electrocardiography PMID: 26720305
  50. since hs-cTnT levels of non-AMI patients can be over the diagnostic cut-off value, further studies are necessary to define clinically applicable cut-off values of hs-cTnT PMID: 26782442

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Involvement in disease Cardiomyopathy, familial hypertrophic 2 (CMH2); Cardiomyopathy, dilated 1D (CMD1D); Cardiomyopathy, familial restrictive 3 (RCM3)
Protein Families Troponin T family
Tissue Specificity Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in
Database Links

HGNC: 11949

OMIM: 115195

KEGG: hsa:7139

STRING: 9606.ENSP00000356286

UniGene: Hs.533613

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