TNPO2 Antibody

Datasheet

Code	CSB-PA024021GA01HU
Size	$600
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Product Details
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Target Background

Product Details

Uniprot No.

O14787

Target Names

TNPO2

Alternative Names

Importin 3 antibody; IPO3 antibody; Karyopherin beta 2b, transportin antibody; Karyopherin beta-2b antibody; KPNB2B antibody; Tnpo2 antibody; TNPO2_HUMAN antibody; Transportin 2 (importin 3, karyopherin beta 2b) antibody; Transportin 2 (Importin 3, karyopherin beta 2b), isoform CRA b antibody; Transportin 2 antibody; Transportin-2 antibody; TRN2 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human TNPO2

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB,IF

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Gene References into Functions

IPO3 binds NEMO, promotes its nuclear import, and is critical for DNA damage-dependent NF-kappaB activation. PMID: 26060253
Studies indicate potential roles of Tranportin-1 and Transportin-2 beyond protein nuclear import. PMID: 24780099
a role for the nuclear trafficking factor TRN2 (transportin 2) through HuR in cell death PMID: 21646354
Nuclear import of fused in sarcoma (FUS) is dependent on Transportin, and interference with this transport pathway leads to cytoplasmic redistribution and recruitment of fused in sarcoma (FUS) into stress granules. PMID: 20606625
Karyopherin beta 2B participates in mRNA export from the nucleus PMID: 12384575
Transportin-2 mediates nuclear import of HuR protein in vitro PMID: 14981248
The structure of Kap beta 2 (also known as Transportin) bound to one of its substrates, the NLS of hnRNP A1, that we report here explains the mechanism of substrate displacement by Ran GTPase. PMID: 16901787

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Subcellular Location

Cytoplasm. Nucleus.

Protein Families

Importin beta family, Importin beta-2 subfamily

Database Links

HGNC: 19998

OMIM: 603002

KEGG: hsa:30000

STRING: 9606.ENSP00000407182

UniGene: Hs.416049

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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