TNS4 Antibody

Code CSB-PA810319LA01HU
Size US$166
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Image
  • IHC image of CSB-PA810319LA01HU diluted at 1:100 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • Western Blot
    Positive WB detected in: Hela whole cell lysate, HepG2 whole cell lysate, PC-3 whole cell lysate, A549 whole cell lysate
    All lanes: TNS4 antibody at 1:1000
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 77 kDa
    Observed band size: 77 kDa

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TNS4 Polyclonal antibody
Uniprot No.
Target Names
TNS4
Alternative Names
C terminal tensin like antibody; C terminal tensin like protein antibody; C-terminal tensin-like protein antibody; CTEN antibody; FLJ14950 antibody; PP14434 antibody; TENS4_HUMAN antibody; Tensin 4 antibody; Tensin-4 antibody; Tns4 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Tensin-4 protein (20-231AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The TNS4 Antibody (Product code: CSB-PA810319LA01HU) is Non-conjugated. For TNS4 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA810319LB01HU TNS4 Antibody, HRP conjugated ELISA
FITC CSB-PA810319LC01HU TNS4 Antibody, FITC conjugated
Biotin CSB-PA810319LD01HU TNS4 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton. May promote apoptosis, via its cleavage by caspase-3.
Gene References into Functions
  1. CTEN activated the expression of TGFB1, thereby prompting epithelial-mesenchymal transition in lung adenocarcinoma cancer cells. PMID: 29985912
  2. Overexpression of the TNS4 gene is a useful independent predictor of outcomes in patients with stage II/III gastric cancer who undergo surgery and receive adjuvant chemotherapy with S-1. PMID: 29102927
  3. Cten-Snail signaling pathway contributes to cell motility in colorectal cancer (CRC), mediated by the stabilization of Snail protein. PMID: 28691764
  4. Conclude that in colorectal cancer, Cten is upregulated by EGFR and Kras but downregulated by STAT3. PMID: 26852686
  5. Tensin4 is up-regulated by EGF-induced ERK1/2 activity and promotes cell proliferation and migration in hepatocellular carcinoma PMID: 26035355
  6. Cten expression mediates invasion of human lung cancer cells and is upregulated by epidermal growth factor via STAT3. PMID: 25439778
  7. Findings indicate that induction of Cten protein expression is a relatively early event in melanoma progression, and that Cten has the potential to serve as a prognostic marker for primary melanoma patients. PMID: 24244691
  8. Up-regulated cten modulates cell migration induced by FGF2. PMID: 23625726
  9. Significant correlation between MET and TNS4 expression in human colon carcinoma and ovarian carcinoma suggests TNS4 plays a critical role in MET stability in cancer. PMID: 24814316
  10. CTEN regulates EGFR protein levels through a posttranslational mechanism. PMID: 23774213
  11. Phylogenetic analysis, expression patterns, and transcriptional regulation of human CTEN gene. PMID: 23500447
  12. Show an oncogenic role for CTEN in pancreatic cancer through promotion of colony formation and cell motility. PMID: 22750970
  13. conclude that, in the colon and pancreas, Cten is a downstream target of Kras and may be a mechanism through which Kras regulates of cell motility PMID: 21698197
  14. Cten expression is of prognostic significance in colorectal carcinoma, and delineate a Cten-ILK pathway controlling cell motility and possibly promoting metastasis. PMID: 21339732
  15. CTEN (C-terminal tensin-like), a novel oncogene overexpressed in invasive breast carcinoma. PMID: 20390342
  16. Increased cten mRNA expression was correlated with tumor progression in lung cancers PMID: 12711115
  17. Cten/GAPDH mRNA expression was correlated with evidence of tumor progression in thymoma. PMID: 15001839
  18. These results provide a novel mechanism whereby the SH2 domain of cten-mediated focal adhesion localization of DLC-1 plays an essential role in its tumor suppression activity. PMID: 17190795
  19. Expression of CTEN correlates with high tumor grade and metastasis to lymph nodes, suggesting that CTEN may contribute to tumor invasiveness. PMID: 17765673
  20. TNS4 mRNA expression was significantly higher in gastric cancer. PMID: 18612693
  21. Cten is a novel nuclear partner of beta-catenin, and has an oncogenic activity in colon cancers. PMID: 19487278
  22. CTEN plays an important role in paclitaxel sensitivity, and CTEN expression level may be a prognostic predictive factor for prostate cancer patients. PMID: 19725034

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Subcellular Location
Cell junction, focal adhesion. Cytoplasm, cytoskeleton.
Tissue Specificity
Prostate and placenta. Down regulated in prostate cancer.
Database Links

HGNC: 24352

OMIM: 608385

KEGG: hsa:84951

STRING: 9606.ENSP00000254051

UniGene: Hs.438292

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