TOM1L1 Antibody, HRP conjugated

Code CSB-PA024044LB01HU
Size US$166
Order now
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TOM1L1 Polyclonal antibody
Uniprot No.
Target Names
TOM1L1
Alternative Names
2310045L10Rik antibody; C80573 antibody; OK/KNS CL.3 antibody; Src activating and signaling molecule antibody; Src activating and signaling molecule protein antibody; Src-activating and signaling molecule protein antibody; SRCASM antibody; Target of Myb like protein 1 antibody; Target of Myb-like protein 1 antibody; Target of myb1 (chicken) homolog like 1 antibody; Target of myb1 (chicken) like 1 antibody; Target of myb1 like 1 antibody; TM1L1_HUMAN antibody; TOM1 L1 antibody; TOM1 like protein 1 antibody; TOM1-like protein 1 antibody; TOM1L1 antibody; TOM1L1 protein antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human TOM1-like protein 1 protein (296-476AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions.
Gene References into Functions
  1. TOM1L1 enhances ERBB2-induced cell invasiveness by promoting invadopodia formation and MT1-MMP trafficking to the plasma membrane. PMID: 26899482
  2. whereas TOM1L1 depletion only slightly affected SRC-induced proliferation of colorectal cancer cells in vitro, it drastically decreased tumor growth in xenografted nude mice. PMID: 23023324
  3. This pattern of Srcasm expression suggests that it may act as a negative regulator in esophageal squamous cell carcinoma cell signaling PMID: 20944134
  4. results imply that TOM1L has a mitogenic effect in Jurkat T-cells and is involved in a novel cell signaling pathway that is crucial for the IL-2 production and STAT3 expression PMID: 20182632
  5. Srcasm plays a role in linking EGF receptor- and SFK-dependent signaling to differentiation in keratinocytes PMID: 15579470
  6. Tom1L1 could act as an intermediary between signaling and degradative pathways. PMID: 15611048
  7. study found that not only the PTAP sequence in the GAT domain but also the PSAP sequence in the C-terminal region of Tom1L1 is responsible for its interaction with the UEV domain of Tsg101 and competes with the HIV-1 Gag protein for the Tsg101 interaction PMID: 18367816
  8. All multicentric and nodular basal cell carcinomas displayed a prominent loss of Srcasm staining in association with a marked increase in Ki-67 staining. PMID: 19220627
  9. Participation of Tom1L1 in EGF-stimulated endocytosis of EGF receptor. PMID: 19798056

Show More

Hide All

Subcellular Location
Golgi apparatus, Golgi stack. Endosome membrane. Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side.
Protein Families
TOM1 family
Database Links

HGNC: 11983

OMIM: 604701

KEGG: hsa:10040

STRING: 9606.ENSP00000460823

UniGene: Hs.153504

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1
webinars: DT3C facilitates antibody internalization X
Place an order now

I. Product details

*
*
*
*

II. Contact details

*
*

III. Ship To

*
*
*
*
*
*
*

IV. Bill To

*
*
*
*
*
*
*
*