TOM1L1 Antibody

1. TOM1L1 enhances ERBB2-induced cell invasiveness by promoting invadopodia formation and MT1-MMP trafficking to the plasma membrane. PMID: 26899482
2. whereas TOM1L1 depletion only slightly affected SRC-induced proliferation of colorectal cancer cells in vitro, it drastically decreased tumor growth in xenografted nude mice. PMID: 23023324
3. This pattern of Srcasm expression suggests that it may act as a negative regulator in esophageal squamous cell carcinoma cell signaling PMID: 20944134
4. results imply that TOM1L has a mitogenic effect in Jurkat T-cells and is involved in a novel cell signaling pathway that is crucial for the IL-2 production and STAT3 expression PMID: 20182632
5. Srcasm plays a role in linking EGF receptor- and SFK-dependent signaling to differentiation in keratinocytes PMID: 15579470
6. Tom1L1 could act as an intermediary between signaling and degradative pathways. PMID: 15611048
7. study found that not only the PTAP sequence in the GAT domain but also the PSAP sequence in the C-terminal region of Tom1L1 is responsible for its interaction with the UEV domain of Tsg101 and competes with the HIV-1 Gag protein for the Tsg101 interaction PMID: 18367816
8. All multicentric and nodular basal cell carcinomas displayed a prominent loss of Srcasm staining in association with a marked increase in Ki-67 staining. PMID: 19220627
9. Participation of Tom1L1 in EGF-stimulated endocytosis of EGF receptor. PMID: 19798056

Show More

Hide All

HGNC: 11983

OMIM: 604701

KEGG: hsa:10040

STRING: 9606.ENSP00000460823

UniGene: Hs.153504