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TRABD2B Antibody, HRP conjugated

Datasheet
Code CSB-PA406235LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TRABD2B Polyclonal antibody
Uniprot No.
A6NFA1
Target Names
TRABD2B
Alternative Names
TRABD2B antibody; HKAT antibody; TIKI2 antibody; Metalloprotease TIKI2 antibody; EC 3.4.-.- antibody; Heart antibody; kidney and adipose-enriched transmembrane protein homolog antibody; TRAB domain-containing protein 2B antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Metalloprotease TIKI2 protein (195-405AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
ELISA Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation.
Gene References into Functions
  1. Results of the present study indicate that TIKI2 is upregulated in renal cell carcinoma tissues and plays an oncogenic role in renal cell carcinoma PMID: 26942462
  2. examination of the structural prediction and identification of the active site residues of human TIKI2 PMID: 26631728
  3. provided evidence that reduced expression of TIKI family protein in osteosarcoma may participate in the progression of osteosarcoma and restoring its expression was able to impair the growth of osteosarcoma PMID: 24771064
  4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Protein Families
TIKI family
Database Links

HGNC: 44200

OMIM: 614913

KEGG: hsa:388630

STRING: 9606.ENSP00000456730

UniGene: Hs.61504

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