TRABD2B Antibody

Code CSB-PA406235LA01HU
Size US$299
Image
  • IHC image of CSB-PA406235LA01HU diluted at 1:100 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • Immunofluorescence staining of Hela cells with CSB-PA406235LA01HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) TRABD2B Polyclonal antibody
Uniprot No. A6NFA1
Target Names TRABD2B
Alternative Names TRABD2B antibody; HKAT antibody; TIKI2 antibody; Metalloprotease TIKI2 antibody; EC 3.4.-.- antibody; Heart antibody; kidney and adipose-enriched transmembrane protein homolog antibody; TRAB domain-containing protein 2B antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Metalloprotease TIKI2 protein (195-405AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated

The TRABD2B Antibody (Product code: CSB-PA406235LA01HU) is Non-conjugated. For TRABD2B Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA406235LB01HU TRABD2B Antibody, HRP conjugated ELISA
FITC CSB-PA406235LC01HU TRABD2B Antibody, FITC conjugated
Biotin CSB-PA406235LD01HU TRABD2B Antibody, Biotin conjugated ELISA
Clonality Polyclonal
Isotype IgG
Purification Method Antigen Affinity Purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation.
Gene References into Functions
  1. Results of the present study indicate that TIKI2 is upregulated in renal cell carcinoma tissues and plays an oncogenic role in renal cell carcinoma PMID: 26942462
  2. examination of the structural prediction and identification of the active site residues of human TIKI2 PMID: 26631728
  3. provided evidence that reduced expression of TIKI family protein in osteosarcoma may participate in the progression of osteosarcoma and restoring its expression was able to impair the growth of osteosarcoma PMID: 24771064
  4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
Subcellular Location Cell membrane; Single-pass type I membrane protein.
Protein Families TIKI family
Database Links

HGNC: 44200

OMIM: 614913

KEGG: hsa:388630

STRING: 9606.ENSP00000456730

UniGene: Hs.61504

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