TRAF7 Antibody

1. TRAF7 mutations icause intraneural perineuriomas. PMID: 28019650
2. TRAF7 is a direct target of miR-126 in human umbilical cord vascular endothelial cells. PMID: 25318608
3. Downregulation of ubiquitin E3 ligase TNF receptor-associated factor 7 leads to stabilization of p53 in breast cancer. PMID: 23128672
4. The findings of this study suggested an essential contribution of combined KLF4 K409Q and TRAF7 mutations in the genesis of secretory meningioma and demonstrate a role for TRAF7 alterations in other non-NF2 meningiomas. PMID: 23404370
5. Nearly one-fourth of all meningiomas have mutations in TRAF7. PMID: 23348505
6. TRAF7 is involved in signal transduction pathways that lead either to activation or repression of NF-kappaB transcription factor. PMID: 22105767
7. an important role for TRAF7 in the activation of JNK following TNFalpha stimulation and involvement of this protein in regulating the turnover of c-FLIP PMID: 22219201
8. this study identifies TRAF7 as a NEMO- and p65-interacting molecule and brings important information on the ubiquitination events that control NF-kappaB transcriptional activity. PMID: 21518757
9. TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis PMID: 15001576

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HGNC: 20456

OMIM: 606692

KEGG: hsa:84231

STRING: 9606.ENSP00000318944

UniGene: Hs.713632