TRAF7 Antibody

Code CSB-PA757671LA01HU
Size US$166
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  • IHC image of CSB-PA757671LA01HU diluted at 1:200 and staining in paraffin-embedded human skeletal muscle tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • Immunofluorescence staining of HepG2 cells with CSB-PA757671LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TRAF7 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
E3 ubiquitin protein ligase TRAF7 antibody; E3 ubiquitin-protein ligase TRAF7 antibody; RFWD1 antibody; Ring finger and WD repeat domain 1 antibody; RING finger and WD repeat-containing protein 1 antibody; RING finger protein 119 antibody; RNF119 antibody; TNF receptor associated factor 7 antibody; TNF receptor-associated factor 7 antibody; TRAF7 antibody; TRAF7_HUMAN antibody
Raised in
Species Reactivity
Recombinant Human E3 ubiquitin-protein ligase TRAF7 protein (1-90AA)
Immunogen Species
Homo sapiens (Human)

The TRAF7 Antibody (Product code: CSB-PA757671LA01HU) is Non-conjugated. For TRAF7 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA757671LB01HU TRAF7 Antibody, HRP conjugated ELISA
FITC CSB-PA757671LC01HU TRAF7 Antibody, FITC conjugated
Biotin CSB-PA757671LD01HU TRAF7 Antibody, Biotin conjugated ELISA
Purification Method
>95%, Protein G purified
It differs from different batches. Please contact us to confirm it.
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Tested Applications
Recommended Dilution
Application Recommended Dilution
IHC 1:200-1:500
IF 1:50-1:200
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MAP3K3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed. Plays a role in the phosphorylation of MAPK1 and/or MAPK3, probably via its interaction with MAP3K3.
Gene References into Functions
  1. TRAF7 mutations icause intraneural perineuriomas. PMID: 28019650
  2. TRAF7 is a direct target of miR-126 in human umbilical cord vascular endothelial cells. PMID: 25318608
  3. Downregulation of ubiquitin E3 ligase TNF receptor-associated factor 7 leads to stabilization of p53 in breast cancer. PMID: 23128672
  4. The findings of this study suggested an essential contribution of combined KLF4 K409Q and TRAF7 mutations in the genesis of secretory meningioma and demonstrate a role for TRAF7 alterations in other non-NF2 meningiomas. PMID: 23404370
  5. Nearly one-fourth of all meningiomas have mutations in TRAF7. PMID: 23348505
  6. TRAF7 is involved in signal transduction pathways that lead either to activation or repression of NF-kappaB transcription factor. PMID: 22105767
  7. an important role for TRAF7 in the activation of JNK following TNFalpha stimulation and involvement of this protein in regulating the turnover of c-FLIP PMID: 22219201
  8. this study identifies TRAF7 as a NEMO- and p65-interacting molecule and brings important information on the ubiquitination events that control NF-kappaB transcriptional activity. PMID: 21518757
  9. TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis PMID: 15001576

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Subcellular Location
Cytoplasmic vesicle. Note=Colocalizes with MAP3K3 to vesicle-like structures throughout the cytoplasm.
Protein Families
WD repeat TRAF7 family
Tissue Specificity
Ubiquitously expressed with high levels in skeletal muscle, heart, colon, spleen, kidney, liver and placenta.
Database Links

HGNC: 20456

OMIM: 606692

KEGG: hsa:84231

STRING: 9606.ENSP00000318944

UniGene: Hs.713632

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