TRDMT1 Antibody, HRP conjugated

Code CSB-PA675694LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TRDMT1 Polyclonal antibody
Uniprot No.
Target Names
TRDMT1
Alternative Names
dDNMT antibody; DmMT 2 antibody; DmMT2 antibody; DNA (cytosine 5 ) methyltransferase 2 antibody; DNA (cytosine 5) methyltransferase like protein 2 antibody; DNA (cytosine-5)-methyltransferase-like protein 2 antibody; DNA 5 cytosine methyltransferase antibody; DNA methyltransferase 2 antibody; DNA methyltransferase homolog HsaIIP antibody; DNA MTase homolog HsaIIP antibody; Dnmt 2 antibody; Dnmt2 antibody; M.HsaIIP antibody; MHsaIIP antibody; nmt 2 antibody; nmt2 antibody; OTTHUMP00000045198 antibody; PuMet antibody; RNMT 1 antibody; RNMT1 antibody; TRDMT 1 antibody; TRDMT_HUMAN antibody; TRDMT1 antibody; tRNA (cytosine 5 ) methyltransferase antibody; tRNA (cytosine(38)-C(5))-methyltransferase antibody; tRNA aspartic acid methyltransferase 1 antibody; tRNA aspartic acid methyltransferase 1 variant 1 antibody; tRNA aspartic acid methyltransferase 1 variant 2 antibody; tRNA aspartic acid methyltransferase 1 variant 3 antibody; tRNA aspartic acid methyltransferase 1 variant 4 antibody; tRNA aspartic acid methyltransferase 1 variant 5 antibody; tRNA aspartic acid methyltransferase 1 variant 8 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human tRNA (cytosine(38)-C(5))-methyltransferase protein (170-269AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp).
Gene References into Functions
  1. Data suggest that, upon HIV-1 infection, DNMT2 is re-localized from the nucleus to cytoplasmic stress granules where DNMT2 methylates HIV-1 messenger RNA; this methylation increases the stability of the HIV-1 RNA genome and up-regulates virus replication; thus, DNMT2 appears to facilitate HIV-1 infection. PMID: 28476776
  2. The strong effect of some of the somatic cancer mutations on DNMT2 activity suggests that these mutations have a functional role in tumorigenesis. PMID: 25747896
  3. Mapped is the tRNA binding site of DNMT2 by systematically mutating surface-exposed lysine and arginine residues to alanine and studying the tRNA methylation activity and binding of the corresponding variants. PMID: 22591353
  4. the role of Dnmt2 in stress granules could represent a primitive cellular defense mechanism against viral infection. PMID: 20864816
  5. identification of residual DNA-(cytosine-C5) methyltransferase activity PMID: 12794065
  6. cDNA microarray analysis identified several genes involved in DNA methylation, such as DNMT2 and DNMT3a that were more highly expressed in LNCaP-r (an androgen sensitive prostate cancer cell line). PMID: 16173030
  7. genetic and biochemical approach revealed that DNMT2 did not methylate DNA but instead methylated aspartic acid transfer RNA (tRNA(Asp)) and that DNMT2 specifically methylated cytosine 38 in the anticodon loop PMID: 16424344
  8. An association study of 45 folate-related genes in spina bifida: Involvement of tRNA aspartic acid methyltransferase 1 (TRDMT1) PMID: 19161160

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Subcellular Location
Cytoplasm.
Protein Families
Class I-like SAM-binding methyltransferase superfamily, C5-methyltransferase family
Tissue Specificity
Ubiquitous. Higher expression in testis, ovary and thymus and at much lower levels in spleen, prostate, colon, small intestine, and peripheral blood leukocytes.
Database Links

HGNC: 2977

OMIM: 602478

KEGG: hsa:1787

STRING: 9606.ENSP00000367030

UniGene: Hs.351665

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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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