TREML2 Antibody

Datasheet

Code	CSB-PA729201LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA729201LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA729201LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) TREML2 Polyclonal antibody

Uniprot No.

Q5T2D2

Target Names

TREML2

Alternative Names

TREML2 antibody; C6orf76 antibody; TLT2 antibody; UNQ6268/PRO20473 antibody; Trem-like transcript 2 protein antibody; TLT-2 antibody; Triggering receptor expressed on myeloid cells-like protein 2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Trem-like transcript 2 protein (19-268AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The TREML2 Antibody (Product code: CSB-PA729201LA01HU) is Non-conjugated. For TREML2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA729201LB01HU	TREML2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA729201LC01HU	TREML2 Antibody, FITC conjugated
Biotin	CSB-PA729201LD01HU	TREML2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation.

Gene References into Functions

Mutation of TREML2 is a major factor leading to ankylosing spondylitis for HLA-B27 (+) members in a large family and that TREML2 is also a susceptibility gene promoting the development of ankylosing spondylitis in HLA-B27 (+) individuals. PMID: 29778423
A missense variant in TREML2 was associated with a reduced risk of Alzheimer's Disease in a Han Chinese population. PMID: 26797517
Study characterized the expression of TREM genes in cerebellum and temporal cortex and determined TREML1 and TREM2 to be the only reliably expressed TREM genes in these brain regions; identified rs9357347 as a putative regulatory variant that is associated with protection from Alzheimer's disease and with increased TREML1 and TREM2 brain levels. PMID: 27939925
Missense variant in TREML2 protects against Alzheimer's disease. PMID: 24439484
TLT2 may be involved in the innate immune response based on its expression profile and the fact that it is up-regulated in response to inflammation. PMID: 16670310
analysis of an interaction between B7-H3 and TLT-2 that preferentially enhances CD8(+) T cell activation PMID: 18650384
Data do not point to a role for TREML2 as a receptor for B7-H3. PMID: 19544488

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Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Tissue Specificity

Detected in cultured B-cells, T-cell leukemia and monocyte leukemia. Expressed constitutively on CD8 T-cells and induced on CD4 T-cells after activation.

Database Links

HGNC: 21092

OMIM: 609715

KEGG: hsa:79865

STRING: 9606.ENSP00000418767

UniGene: Hs.164797

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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