TREML2 Antibody

Code CSB-PA729201LA01HU
Size US$299Purchase it in Cusabio online store
(only available for customers from the US)
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  • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA729201LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA729201LA01HU at dilution of 1:100

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) TREML2 Polyclonal antibody
Uniprot No. Q5T2D2
Target Names TREML2
Alternative Names TREML2 antibody; C6orf76 antibody; TLT2 antibody; UNQ6268/PRO20473 antibody; Trem-like transcript 2 protein antibody; TLT-2 antibody; Triggering receptor expressed on myeloid cells-like protein 2 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Trem-like transcript 2 protein (19-268AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation.
Gene References into Functions
  1. Mutation of TREML2 is a major factor leading to ankylosing spondylitis for HLA-B27 (+) members in a large family and that TREML2 is also a susceptibility gene promoting the development of ankylosing spondylitis in HLA-B27 (+) individuals. PMID: 29778423
  2. A missense variant in TREML2 was associated with a reduced risk of Alzheimer's Disease in a Han Chinese population. PMID: 26797517
  3. Study characterized the expression of TREM genes in cerebellum and temporal cortex and determined TREML1 and TREM2 to be the only reliably expressed TREM genes in these brain regions; identified rs9357347 as a putative regulatory variant that is associated with protection from Alzheimer's disease and with increased TREML1 and TREM2 brain levels. PMID: 27939925
  4. Missense variant in TREML2 protects against Alzheimer's disease. PMID: 24439484
  5. TLT2 may be involved in the innate immune response based on its expression profile and the fact that it is up-regulated in response to inflammation. PMID: 16670310
  6. analysis of an interaction between B7-H3 and TLT-2 that preferentially enhances CD8(+) T cell activation PMID: 18650384
  7. Data do not point to a role for TREML2 as a receptor for B7-H3. PMID: 19544488

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Subcellular Location Cell membrane, Single-pass type I membrane protein
Tissue Specificity Detected in cultured B-cells, T-cell leukemia and monocyte leukemia. Expressed constitutively on CD8 T-cells and induced on CD4 T-cells after activation.
Database Links

HGNC: 21092

OMIM: 609715

KEGG: hsa:79865

STRING: 9606.ENSP00000418767

UniGene: Hs.164797

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