TREML2 Antibody, Biotin conjugated

1. Mutation of TREML2 is a major factor leading to ankylosing spondylitis for HLA-B27 (+) members in a large family and that TREML2 is also a susceptibility gene promoting the development of ankylosing spondylitis in HLA-B27 (+) individuals. PMID: 29778423
2. A missense variant in TREML2 was associated with a reduced risk of Alzheimer's Disease in a Han Chinese population. PMID: 26797517
3. Study characterized the expression of TREM genes in cerebellum and temporal cortex and determined TREML1 and TREM2 to be the only reliably expressed TREM genes in these brain regions; identified rs9357347 as a putative regulatory variant that is associated with protection from Alzheimer's disease and with increased TREML1 and TREM2 brain levels. PMID: 27939925
4. Missense variant in TREML2 protects against Alzheimer's disease. PMID: 24439484
5. TLT2 may be involved in the innate immune response based on its expression profile and the fact that it is up-regulated in response to inflammation. PMID: 16670310
6. analysis of an interaction between B7-H3 and TLT-2 that preferentially enhances CD8(+) T cell activation PMID: 18650384
7. Data do not point to a role for TREML2 as a receptor for B7-H3. PMID: 19544488

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HGNC: 21092

OMIM: 609715

KEGG: hsa:79865

STRING: 9606.ENSP00000418767

UniGene: Hs.164797