TRIAP1 Antibody

Code CSB-PA024443ESR1HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA024443ESR1HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA024443ESR1HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TRIAP1 Polyclonal antibody
Uniprot No.
Target Names
TRIAP1
Alternative Names
p53-inducible cell-survival factor antibody; p53CSV antibody; Protein 15E1.1 antibody; TP53-regulated inhibitor of apoptosis 1 antibody; TRIA1_HUMAN antibody; Triap1 antibody; WF 1 antibody; WF1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human TP53-regulated inhibitor of apoptosis 1 protein (1-76AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Likewise, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo). Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis.
Gene References into Functions
  1. TRIAP1 is regulated by miR-320b and has a role in progression in nasopharyngeal carcinoma PMID: 27428374
  2. Results describe the upregulation of TRIAP1 in drugresistant breast cancer cells. Its experimental modulation changed breast tumor cells sensitivity to doxorubicin, thus confirming its role in drug resistance. PMID: 25998939
  3. TRIAP1 is Conserved Specific Coregulators of the p21:PUMA Expression Ratio. PMID: 23684607
  4. Under specific conditions of stress, p53 regulates transcription of p53CSV and that p53CSV is one of the important players in the p53-mediated cell survival. PMID: 15735003
  5. Upregulated in at least 50% of multiple myeloma cases tested. PMID: 19171422
  6. HSPC132 is p53CSV, a novel p53-inducible gene involved in the p53-dependent cell-survival pathway PMID: 15735003

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Subcellular Location
Mitochondrion. Mitochondrion intermembrane space.
Protein Families
TRIAP1/MDM35 family
Database Links

HGNC: 26937

OMIM: 614943

KEGG: hsa:51499

STRING: 9606.ENSP00000449795

UniGene: Hs.69499

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