TRIM2 Antibody

Code CSB-PA024456GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
TRIM2
Alternative Names
E3 ubiquitin protein ligase TRIM2 antibody; KIAA0517 antibody; RING finger protein 86 antibody; RNF86 antibody; Trim2 antibody; TRIM2_HUMAN antibody; Tripartite motif containing 2 antibody; Tripartite motif protein 2 antibody; Tripartite motif protein TRIM2 antibody; Tripartite motif-containing 2 antibody; Tripartite motif-containing protein 2 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human TRIM2
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IF
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance.
Gene References into Functions
  1. Study revealed that TRIM2 performs important functions in regulating the development and metastasis of osteosarcoma. PMID: 30066883
  2. TRIM2 is associated with clinical fibrotic phenotypes of eosinophilic esophagitis. PMID: 29628359
  3. We found that CREBRF and TRIM2 mRNA were significantly upregulated by rHDL, particularly in response to its phospholipid component 1-palmitoyl-2-linoleoyl-phosphatidylcholine, however, protein expression was not significantly altered. PMID: 29958463
  4. TRIM2 homozygous missense mutation (c.2000A>C; p.D667A) in a patient with peripheral neuropathy and bilateral vocal cord paralysis PMID: 25893792
  5. The functional role of the C-terminal NHL domain was characterized in TRIM2. PMID: 24817735
  6. TRIM2 is repressed by miR-9 and -181c, either alone or in combination. PMID: 21720722

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Involvement in disease
Charcot-Marie-Tooth disease 2R (CMT2R)
Subcellular Location
Cytoplasm.
Protein Families
TRIM/RBCC family
Database Links

HGNC: 15974

OMIM: 614141

KEGG: hsa:23321

STRING: 9606.ENSP00000339659

UniGene: Hs.435711

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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