TRIM23 Antibody

Datasheet

Code	CSB-PA024459ESR1HU
Size	US$166
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Image	Western blot All lanes: TRIM23 antibody at 4.55 μg/ml + Raw264.7 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 65, 64, 62 kDa Observed band size: 65, 35 kDa Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA024459ESR1HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human thyroid tissue using CSB-PA024459ESR1HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) TRIM23 Polyclonal antibody

Uniprot No.

P36406

Target Names

TRIM23

Alternative Names

ADP ribosylation factor domain protein 1 antibody; ADP-ribosylation factor domain-containing protein 1 antibody; ARF domain protein 1 antibody; ARFD1 antibody; E3 ubiquitin-protein ligase TRIM23 antibody; GTP binding protein ARD 1 antibody; GTP-binding protein ARD-1 antibody; N-acetyltransferase ARD1 human homolog of antibody; N-acetyltransferase homolog of S. cerevisiae ARD1 antibody; RING finger protein 46 antibody; TRI23_HUMAN antibody; TRIM23 antibody; Tripartite motif protein TRIM23 antibody; Tripartite motif-containing protein 23 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human E3 ubiquitin-protein ligase TRIM23 protein (1-280AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Acts as an E3 ubiquitin-protein ligase. Plays an essential role in autophagy activation during viral infection. Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1. In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes.; (Microbial infection) Mediates TRAF6 auto-ubiquitination in the presence of human cytomegalovirus protein UL144, resulting in the virally controlled activation of NF-kappa-B stimulation at early times of HCMV infection.

Gene References into Functions

TRIM23 may be associated with progression of gastric cancer PMID: 30477642
work identifies the TRIM23-TBK1-p62 axis as a key component of selective autophagy and further reveals a role for K27-linked ubiquitination in GTPase-dependent TBK1 activation PMID: 28871090
Our results indicate that TRIM23 enzymatic activity requires RING dimerization, consistent with the general model of TRIM activation PMID: 28681414
TRIM23 regulates adipocyte differentiation via stabilization of the adipogenic activator PPARgamma2. PMID: 25905670
conclude that TRIM23-mediated ubiquitin conjugation to NEMO is essential for TLR3- and RIG-I/MDA5-mediated antiviral innate and inflammatory responses PMID: 20724660
Data are consistent with a potential function for ADP-ribosylation factor domain protein 1 as an E3 ubiquitin ligase in cells. PMID: 15684077
The authors present a novel role for TRIM23 that is specific to UL144-mediated activation of NF-kappaB during the course of virus infection. PMID: 19176615

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Subcellular Location

Cytoplasm. Endomembrane system. Golgi apparatus membrane. Lysosome membrane. Note=Membrane-associated with the Golgi complex and lysosomal structures.

Protein Families

Small GTPase superfamily, Arf family

Database Links

HGNC: 660

OMIM: 601747

KEGG: hsa:373

STRING: 9606.ENSP00000231524

UniGene: Hs.792

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Service

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Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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