TRIM26 Antibody

Code CSB-PA619638LA01HU
See More Details Free Antibody trial simple
Size US$299
Uniprot No. Q12899
  • IHC image of CSB-PA619638LA01HU diluted at 1:300 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Recombinant Human Tripartite motif-containing protein 26 protein (151-270AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA, IHC; Recommended dilution: IHC:1:200-1:500
Relevance cytosol, DNA binding, metal ion binding, innate immune response, interferon-gamma-mediated signaling pathway, negative regulation of viral entry into host cell, negative regulation of viral release from host cell, positive regulation of sequence-specific DNA binding transcription factor activity
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Tripartite motif-containing protein 26 (EC (Acid finger protein) (AFP) (RING finger protein 95) (Zinc finger protein 173), TRIM26, RNF95 ZNF173
Immunogen Species Human
Research Area Epigenetics and Nuclear Signaling
Target Names TRIM26
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function E3 ubiquitin-protein ligase which regulates the IFN-beta production and antiviral response downstream of various DNA-encoded pattern-recognition receptors (PRRs). Promotes nuclear IRF3 ubiquitination and proteasomal degradation. Bridges together TBK1 and NEMO during the innate response to viral infection leading to the activation of TBK1.
Subcellular Location Cytoplasm, Nucleus
Protein Families TRIM/RBCC family
Database Links

HGNC: 12962

OMIM: 600830

KEGG: hsa:7726

STRING: 9606.ENSP00000391879

UniGene: Hs.485041

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