TROVE2 Antibody, Biotin conjugated

Code CSB-PA13749D0Rb
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TROVE2 Polyclonal antibody
Uniprot No.
Target Names
TROVE2
Alternative Names
60 kDa ribonucleoprotein Ro antibody; 60 kDa Ro protein antibody; 60 kDa SS A/Ro ribonucleoprotein antibody; 60 kDa SS-A/Ro ribonucleoprotein antibody; Autoantigen Ro/SSA, 60-KD antibody; bA101E13.2 antibody; Gastric cancer multi drug resistance protein antibody; Ribonucleoprotein autoantigen SS A/Ro antibody; RO 60 antibody; Ro 60 kDa autoantigen antibody; RO60 antibody; RO60_HUMAN antibody; RoRNP antibody; Sjoegren syndrome antigen A2 antibody; Sjoegren syndrome type A antigen antibody; Sjogren syndrome antigen A2 (60kD ribonucleoprotein autoantigen SS A/Ro) antibody; Sjogren syndrome antigen A2 (60kDa ribonucleoprotein autoantigen SS A/Ro) antibody; Sjogren syndrome antigen A2 antibody; SS A antibody; SS-A antibody; SS-A/Ro antibody; SSA 2 antibody; SSA antibody; SSA2 antibody; TROVE 2 antibody; TROVE domain family member 2 antibody; TROVE2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human 60 kDa SS-A/Ro ribonucleoprotein protein (3-535AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs. May stabilize some of these RNAs and protect them from degradation. Binds to endogenous Alu retroelements which are induced by type I interferon and stimulate porinflammaotry cytokine secretion. Regulates the expression of Alu retroelements as well as inflammatory genes.; May play roles in cilia formation and/or maintenance.
Gene References into Functions
  1. TROVE2 is a novel target of miR-128 in astrocytoma tissues and the expression of TROVE2 is increased with the pathological stages increasing. PMID: 26307612
  2. Significant relationships were found between clinical and laboratory manifestations of autoimmune and rheumatic diseases with different patterns of antibodies to anti-Ro52, anti-Ro60 and anti-La. PMID: 26725021
  3. These findings establish a link among the lupus autoantigen Ro60, Alu retroelements, and type I interferon. PMID: 26382853
  4. Findings indicate a relentless turnover of short-lived clonotypic variants, masquerading as long-lived Ro60 humoral autoimmunity. PMID: 23644453
  5. The Y3 RNA moiety of the Ro60 ribonucleoprotein plays a critical role in the pathogenesis of fetal cardiac injury by altering the subcellular location of Ro60 autoantibodies. PMID: 23698747
  6. these data indicate that ZBP1 may function as an adapter to export the Ro/Y3 RNA complex from nuclei. PMID: 22114317
  7. conclude that RNPs containing hY RNAs and Ro60, La or nucleolin are not required for the function of hY RNAs in chromosomal DNA replication in a human cell-free system, which can be mediated by Y RNAs outside of these RNPs PMID: 21060685
  8. dichotomy of human autoantibody responses against mutually exclusive determinants linked to a single domain of a systemic autoantigen and supports a model in which tolerance is broken by different immunogenic forms of Ro 60 PMID: 20131295
  9. Activation of Toll-like receptors by fetal factor Ro60-associated single-stranded RNA particles is relevant in autoimmune-associated congenital heart block, where the obligate maternal factor is an anti-SSA/Ro autoantibody. PMID: 20089705
  10. In viitro RNA chaperone activity of SSA2 was studied. PMID: 15928345
  11. The structural organization and Zn2+-dependent subdomain interactions involving autoiantigenic epitopes in the RBBC region of SS-A were studied. PMID: 15964842
  12. interactions between Ro-Y5 and L5-5S RNPs establish 5S RNA as a target of quality control PMID: 18056422
  13. results demonstrate that Ro 60 functions as a novel receptor for beta(2)GPI on the surface of apoptotic cells. The formation of Ro 60-beta(2)GPI complexes may protect against anti-Ro 60 autoantibody-mediated tissue injury. PMID: 19248095

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Subcellular Location
Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Protein Families
Ro 60 kDa family
Database Links

HGNC: 11313

OMIM: 600063

KEGG: hsa:6738

STRING: 9606.ENSP00000356411

UniGene: Hs.288178

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